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Difference between revisions of "Case 85"
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(Created page with "===Provided clinical history=== 78 year old man ===Site=== Right epididymis - mass ===Primary image=== Image: Papillary cystadenoma of epididymis -- very low mag.jpg |500p...") |
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===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>Paratesticular mass (unilateral) on testicular US. Patient feels well. No history of malignancy. Abdominal US is negative. Patient has hypercholesterolemia and high blood pressure.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center>This makes me think of [[von Hippel-Lindau]]. Is it unilateral or bilateral?</center>}} | {{hidden|Ask a colleague|<center>This makes me think of [[von Hippel-Lindau disease]]. Is it unilateral or bilateral?</center>}} | ||
====Stains==== | ====Stains==== | ||
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===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>[[ | {{hidden|Diagnosis|<center>[[Papillary cystadenoma of the epididymis]]</center><br> | ||
Comment:<br>This may occur in [[von Hippel-Lindau disease]]. In the context of von Hippel-Lindau disease, it is usually bilateral and the patient is younger. | |||
The main (morphologic) differential diagnosis is [[clear cell renal cell carcinoma]]. | |||
The immunoprofile of this lesion is like [[clear cell tubulopapillary renal cell carcinoma]] (also known as ''clear cell papillary RCC''); it is CK7 positive, CD10 negative, AMACR negative, PAX8 positive.<ref name=pmid24441657>{{Cite journal | last1 = Cox | first1 = R. | last2 = Vang | first2 = R. | last3 = Epstein | first3 = JI. | title = Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma. | journal = Am J Surg Pathol | volume = 38 | issue = 5 | pages = 713-8 | month = May | year = 2014 | doi = 10.1097/PAS.0000000000000152 | PMID = 24441657 }}</ref> One should check if there is a kidney mass. | |||
===Reference=== | |||
{{Reflist|1}} | |||
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<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
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[[Category:Cases in genitourinary pathology]] | [[Category:Cases in genitourinary pathology]] | ||
[[Category:Cases in genitourinary pathology - fellow]] | [[Category:Cases in genitourinary pathology - fellow and expert]] | ||
[[Category:Cases difficulty 6]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | [[Category:Cases difficulty 6]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||