Difference between revisions of "Cribriform adenocarcinoma of the minor salivary gland"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Cribriform adenocarcinoma of the minor salivary gland. [[H&E stain]]. | ||
| Synonyms = cribriform adenocarcioma of the tongue | | Synonyms = cribriform adenocarcioma of the tongue | ||
| Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium | | Micro = cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium | ||
| Line 52: | Line 52: | ||
===Images=== | ===Images=== | ||
www | <gallery> | ||
Image: Cribriform adenocarcinoma of the tongue -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue -- very high mag.jpg | CAT - very high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- low mag.jpg | CAT - low mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a1b -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- intermed mag.jpg | CAT - intermed. mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- high mag.jpg | CAT - high mag. | |||
Image: Cribriform adenocarcinoma of the tongue - a2 -- very high mag.jpg | CAT - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig1/ CAMSG (nih.gov)].<ref name=pmid23821209/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712093/figure/Fig3/ CAMSG (nih.gov)].<ref name=pmid23821209>{{Cite journal | last1 = Michal | first1 = M. | last2 = Kacerovska | first2 = D. | last3 = Kazakov | first3 = DV. | title = Cribriform adenocarcinoma of the tongue and minor salivary glands: a review. | journal = Head Neck Pathol | volume = 7 Suppl 1 | issue = | pages = S3-11 | month = Jul | year = 2013 | doi = 10.1007/s12105-013-0457-9 | PMID = 23821209 }}</ref> | ||
Revision as of 22:06, 18 May 2015
| Cribriform adenocarcinoma of the minor salivary gland | |
|---|---|
| Diagnosis in short | |
 Cribriform adenocarcinoma of the minor salivary gland. H&E stain. | |
|
| |
| Synonyms | cribriform adenocarcioma of the tongue |
|
| |
| LM | cribriform and solid architecture, cytology similar to papillary thyroid carcinoma (irregular nuclear membranes, nuclear overlap), usually covered by an intact squamous epithelium |
| LM DDx | polymorphous low grade adenocarcinoma, papillary thyroid carcinoma |
| IHC | CK7 +ve, vimentin +ve, CD117 -ve/+ve, S-100 +ve |
| Site | head and neck - usually tongue |
|
| |
| Prevalence | very rare |
| Prognosis | good |
| Clin. DDx | other salivary gland tumours |
| Treatment | excision |
Cribriform adenocarcinoma of the minor salivary gland, abbreviated CAMSG, is a rare malignancy of the salivary gland, typically of the tongue.[1]
It is also known as cribriform adenocarcioma of the tongue, abbreviated CAT.
General
- Rare - small case series and case reports.
- Typically tongue - first described there.[2]
- Good prognosis[1] - on limited data.
Microscopic
Features:
- Typically covered by an intact squamous epithelium.[1]
- Growth patterns - cribriform and solid.
- Cytology similar to papillary thyroid carcinoma.[1]
- Irregular nuclear membranes (raisin-like nuclei).
- Nuclear overlap.
DDx:
- Polymorphous low grade adenocarcinoma - morphology more varied.
- Papillary thyroid carcinoma.
Images
CAT - low mag.
CAT - intermed. mag.
CAT - high mag.
CAT - very high mag.
CAT - low mag.
CAT - intermed. mag.
CAT - intermed. mag.
CAT - intermed. mag.
CAT - high mag.
CAT - very high mag.
www
IHC
Features:[1]
- AE1/AE3 +ve (12/12 cases).
- CAM5.2 +ve (12/12 cases).
- CK7 +ve (12/12 cases).
- CK8 +ve (12/12 cases).
- CK18 +ve (12/12 cases).
- S-100 +ve (12/12 cases).
- Vimentin +ve (12/12 cases).
- CD117 -ve/+ve (5+ve/12 cases).
See also
Referencess
- ↑ 1.0 1.1 1.2 1.3 1.4 Skalova, A.; Sima, R.; Kaspirkova-Nemcova, J.; Simpson, RH.; Elmberger, G.; Leivo, I.; Di Palma, S.; Jirasek, T. et al. (Aug 2011). "Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity.". Am J Surg Pathol 35 (8): 1168-76. doi:10.1097/PAS.0b013e31821e1f54. PMID 21716087.
- ↑ Michal, M.; Skálová, A.; Simpson, RH.; Raslan, WF.; Curík, R.; Leivo, I.; Mukensnábl, P. (Dec 1999). "Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue.". Histopathology 35 (6): 495-501. PMID 10583573.
- ↑ 3.0 3.1 Michal, M.; Kacerovska, D.; Kazakov, DV. (Jul 2013). "Cribriform adenocarcinoma of the tongue and minor salivary glands: a review.". Head Neck Pathol 7 Suppl 1: S3-11. doi:10.1007/s12105-013-0457-9. PMID 23821209.