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Difference between revisions of "Glycogenic acanthosis of the esophagus"
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Glycogenic acanthosis of the esophagus (view source)
Revision as of 10:44, 16 May 2015
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'''Glycogenic acanthosis of the esophagus''' is an uncommon benign change of the [[esophagus]] with a distinctive endoscopic appearance. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Acanthosis_and_superficial_clearing_of_the_esophagus_-_alt_--_intermed_mag.jpg | |||
| Width = | |||
| Caption = Glycogenic acanthosis of the esophagus. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = squamous epithelium with (1) superficial clearing of the cytoplasm, and (2) thickening | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = PAS +ve, PASD -ve | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[esophagus]] | |||
| Assdx = possibly associated with [[gastroesophageal reflux disease]] | |||
| Syndromes = possibly [[Cowden's disease]] when diffuse | |||
| Clinicalhx = ingestion of hot liquids (???) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = raised grey/white lesions | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Glycogenic acanthosis of the esophagus''', abbreviated '''GAE''', is an uncommon benign change of the [[esophagus]] with a distinctive endoscopic appearance. | |||
==General== | ==General== | ||
*Uncommon - seen 3.5% of consecutive 2328 upper endoscopies.<ref name=pmid8409304>{{Cite journal | last1 = Vadva | first1 = MD. | last2 = Triadafilopoulos | first2 = G. | title = Glycogenic acanthosis of the esophagus and gastroesophageal reflux. | journal = J Clin Gastroenterol | volume = 17 | issue = 1 | pages = 79-83 | month = Jul | year = 1993 | doi = | PMID = 8409304 }}</ref> | *Uncommon - seen 3.5% of consecutive 2328 upper endoscopies.<ref name=pmid8409304>{{Cite journal | last1 = Vadva | first1 = MD. | last2 = Triadafilopoulos | first2 = G. | title = Glycogenic acanthosis of the esophagus and gastroesophageal reflux. | journal = J Clin Gastroenterol | volume = 17 | issue = 1 | pages = 79-83 | month = Jul | year = 1993 | doi = | PMID = 8409304 }}</ref> | ||
*Benign.<ref name=pmid25632181>{{Cite journal | last1 = Tsai | first1 = SJ. | last2 = Lin | first2 = CC. | last3 = Chang | first3 = CW. | last4 = Hung | first4 = CY. | last5 = Shieh | first5 = TY. | last6 = Wang | first6 = HY. | last7 = Shih | first7 = SC. | last8 = Chen | first8 = MJ. | title = Benign esophageal lesions: endoscopic and pathologic features. | journal = World J Gastroenterol | volume = 21 | issue = 4 | pages = 1091-8 | month = Jan | year = 2015 | doi = 10.3748/wjg.v21.i4.1091 | PMID = 25632181 }}</ref> | *Benign.<ref name=pmid25632181>{{Cite journal | last1 = Tsai | first1 = SJ. | last2 = Lin | first2 = CC. | last3 = Chang | first3 = CW. | last4 = Hung | first4 = CY. | last5 = Shieh | first5 = TY. | last6 = Wang | first6 = HY. | last7 = Shih | first7 = SC. | last8 = Chen | first8 = MJ. | title = Benign esophageal lesions: endoscopic and pathologic features. | journal = World J Gastroenterol | volume = 21 | issue = 4 | pages = 1091-8 | month = Jan | year = 2015 | doi = 10.3748/wjg.v21.i4.1091 | PMID = 25632181 }}</ref> | ||
*May be associated with [[GERD]];<ref name=pmid8409304/> however, lesions do not resolve with [[PPI]] treatment.<ref name=pmid25632181/> | *May be associated with [[GERD]];<ref name=pmid8409304/><ref name=pmid22798107>{{Cite journal | last1 = Nazligül | first1 = Y. | last2 = Aslan | first2 = M. | last3 = Esen | first3 = R. | last4 = Yeniova | first4 = AÖ. | last5 = Kefeli | first5 = A. | last6 = Küçükazman | first6 = M. | last7 = Dülger | first7 = AC. | last8 = Celik | first8 = Y. | title = Benign glycogenic acanthosis lesions of the esophagus. | journal = Turk J Gastroenterol | volume = 23 | issue = 3 | pages = 199-202 | month = Jun | year = 2012 | doi = | PMID = 22798107 }}</ref> however, lesions do not resolve with [[Proton pump inhibitor|PPI]] treatment.<ref name=pmid25632181/> | ||
*Possible association with ingestion of hot liquids.<ref name=pmid20524767/> | *Possible association with ingestion of hot liquids.<ref name=pmid20524767/> | ||
*Described in the context of [[Cowden's disease]] when seen diffusely.<ref name=pmid9177527>{{Cite journal | last1 = Kay | first1 = PS. | last2 = Soetikno | first2 = RM. | last3 = Mindelzun | first3 = R. | last4 = Young | first4 = HS. | title = Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease. | journal = Am J Gastroenterol | volume = 92 | issue = 6 | pages = 1038-40 | month = Jun | year = 1997 | doi = | PMID = 9177527 }}</ref> | |||
==Gross/endoscopic== | ==Gross/endoscopic== | ||
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**Superficial clearing of the cytoplasm. | **Superficial clearing of the cytoplasm. | ||
**Thickening. | **Thickening. | ||
*No significant [[nuclear atypia]]. | |||
===Images=== | ===Images=== | ||
| Line 32: | Line 65: | ||
====www==== | ====www==== | ||
*[http://scielo.isciii.es/pdf/diges/v102n5/carta3.pdf Glycogenic acanthosis (isciii.es)]. | *[http://scielo.isciii.es/pdf/diges/v102n5/carta3.pdf Glycogenic acanthosis (isciii.es)]. | ||
==Stains== | |||
Features:<ref name=pmid6981928>{{Cite journal | last1 = Glick | first1 = SN. | last2 = Teplick | first2 = SK. | last3 = Goldstein | first3 = J. | last4 = Stead | first4 = JA. | last5 = Zitomer | first5 = N. | title = Glycogenic acanthosis of the esophagus. | journal = AJR Am J Roentgenol | volume = 139 | issue = 4 | pages = 683-8 | month = Oct | year = 1982 | doi = 10.2214/ajr.139.4.683 | PMID = 6981928 }}</ref> | |||
*[[PAS stain|PAS]] +ve. | |||
*[[PASD stain|PASD]] -ve. | |||
==See also== | ==See also== | ||