Intracystic papillary carcinoma of the breast: Difference between revisions
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Breast PapillaryCarcinomaEncysted PA.JPG | | Image = Breast PapillaryCarcinomaEncysted PA.JPG | ||
| Width = | | Width = | ||
| Caption = Intracystic Papillary Breast Carcinoma. [[H&E stain]]. | | Caption = Intracystic Papillary Breast Carcinoma. [[H&E stain]]. | ||
| Line 19: | Line 19: | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = +/-bloody discharge from nipple | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = Rare | | Prevalence = Rare | ||
| Line 27: | Line 27: | ||
| Prognosis = very good | | Prognosis = very good | ||
| Other = | | Other = | ||
| ClinDDx = other breast | | ClinDDx = other breast tumours | ||
| Tx = surgical | | Tx = surgical | ||
}} | }} | ||
'''Intracystic papillary carcinoma of the breast''', also known as '''encapsulated papillary carcinoma of the breast''' (abbreviated '''EPC'''), is an uncommon type of [[breast cancer]] with a very good prognosis. | '''Intracystic papillary carcinoma of the breast''', also known as '''encapsulated papillary carcinoma of the breast''' (abbreviated '''EPC'''), is an uncommon type of [[breast cancer]] with a very good prognosis. | ||
It should not be confused with the ''[[invasive papillary carcinoma of the breast]]'', a more aggressive tumour of the breast. | |||
==General== | ==General== | ||
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**Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | **Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | ||
</ref>. | </ref>. | ||
***These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15. | ***These cells are so-called globoid cells or clear cells and are immunoreactive for [[GCDFP-15]]. | ||
***They should not be mistaken for myoepithelial cells. | ***They should not be mistaken for myoepithelial cells. | ||
**Neoplastic epithelial cells: | **Neoplastic epithelial cells: | ||
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Notes: | Notes: | ||
*Many potential pitfalls with papillary breast lesions on needle core biopsy. | *Many potential pitfalls with papillary breast lesions on needle core biopsy. | ||
**Complete excision is recommended<ref>{{Cite journal | last1 = Rizzo | first1 = M. | last2 = Linebarger | first2 = J. | last3 = Lowe | first3 = MC. | last4 = Pan | first4 = L. | last5 = Gabram | first5 = SG. | last6 = Vasquez | first6 = L. | last7 = Cohen | first7 = MA. | last8 = Mosunjac | first8 = M. | title = Management of papillary breast lesions diagnosed on core-needle biopsy: clinical pathologic and radiologic analysis of 276 cases with surgical follow-up. | journal = J Am Coll Surg | volume = 214 | issue = 3 | pages = 280-7 | month = Mar | year = 2012 | doi = 10.1016/j.jamcollsurg.2011.12.005 | PMID = 22244207 }}</ref> | **Complete excision is recommended.<ref name=pmid22244207>{{Cite journal | last1 = Rizzo | first1 = M. | last2 = Linebarger | first2 = J. | last3 = Lowe | first3 = MC. | last4 = Pan | first4 = L. | last5 = Gabram | first5 = SG. | last6 = Vasquez | first6 = L. | last7 = Cohen | first7 = MA. | last8 = Mosunjac | first8 = M. | title = Management of papillary breast lesions diagnosed on core-needle biopsy: clinical pathologic and radiologic analysis of 276 cases with surgical follow-up. | journal = J Am Coll Surg | volume = 214 | issue = 3 | pages = 280-7 | month = Mar | year = 2012 | doi = 10.1016/j.jamcollsurg.2011.12.005 | PMID = 22244207 }}</ref> | ||
*Adequately and carefully sample the specimen to exclude an invasive component. | *Adequately and carefully sample the specimen to exclude an invasive component. | ||
*Report only the size of the invasive component (if present) to prevent over-estimation of tumor stage. | *Report only the size of the invasive component (if present) to prevent over-estimation of tumor stage. | ||
DDx<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | DDx:<ref name=pmid18171414>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | ||
</ref><ref>{{Cite journal | last1 = Pathmanathan | first1 = N. | last2 = Albertini | first2 = AF. | last3 = Provan | first3 = PJ. | last4 = Milliken | first4 = JS. | last5 = Salisbury | first5 = EL. | last6 = Bilous | first6 = AM. | last7 = Byth | first7 = K. | last8 = Balleine | first8 = RL. | title = Diagnostic evaluation of papillary lesions of the breast on core biopsy. | journal = Mod Pathol | volume = 23 | issue = 7 | pages = 1021-8 | month = Jul | year = 2010 | doi = 10.1038/modpathol.2010.81 | PMID = 20473278 }}</ref>: | </ref><ref>{{Cite journal | last1 = Pathmanathan | first1 = N. | last2 = Albertini | first2 = AF. | last3 = Provan | first3 = PJ. | last4 = Milliken | first4 = JS. | last5 = Salisbury | first5 = EL. | last6 = Bilous | first6 = AM. | last7 = Byth | first7 = K. | last8 = Balleine | first8 = RL. | title = Diagnostic evaluation of papillary lesions of the breast on core biopsy. | journal = Mod Pathol | volume = 23 | issue = 7 | pages = 1021-8 | month = Jul | year = 2010 | doi = 10.1038/modpathol.2010.81 | PMID = 20473278 }}</ref>: | ||
*[[Intraductal papilloma]]. | *[[Intraductal papilloma]]. | ||
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***ER staining will be heterologous in a benign lesion. | ***ER staining will be heterologous in a benign lesion. | ||
***Myoepithelial markers (calponin/p63/SMA +ve)s hould be positive in a benign lesion. | ***Myoepithelial markers (calponin/p63/SMA +ve)s hould be positive in a benign lesion. | ||
*[[Papillary ductal carcinoma in situ]] | *[[Papillary ductal carcinoma in situ]]. | ||
**Papillary DCIS shows myoepithelial cells (calponin/p63/SMA +ve) at the periphery of the involved spaces | **Papillary DCIS shows myoepithelial cells (calponin/p63/SMA +ve) at the periphery of the involved spaces | ||
**But papillary DCIS should be negative for myoepithelial cells within the focus of DCIS | **But papillary DCIS should be negative for myoepithelial cells within the focus of DCIS | ||
**Papillary intracystic carcinoma does not show myoepithelial cells at the periphery of the involved spaces | **Papillary intracystic carcinoma does not show myoepithelial cells at the periphery of the involved spaces | ||
*Invasive papillary carcinoma of the breast | *[[Invasive papillary carcinoma of the breast]]. | ||
**Similar architecture but no cystic space, frankly invasive. | **Similar architecture but no cystic space, frankly invasive. | ||
**Very rare. | **Very rare. | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category: | [[Category:Breast pathology]] | ||