Difference between revisions of "P16"
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==Tumours== | ==Tumours== | ||
===Positive=== | ===Positive=== | ||
*Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC. | *[[Squamous cell carcinoma]] - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC. | ||
*High grade [[urothelial carcinoma]] ~86% of cases.<ref name=pmid25069600>{{Cite journal | last1 = Piaton | first1 = E. | last2 = Casalegno | first2 = JS. | last3 = Advenier | first3 = AS. | last4 = Decaussin-Petrucci | first4 = M. | last5 = Mege-Lechevallier | first5 = F. | last6 = Ruffion | first6 = A. | last7 = Mekki | first7 = Y. | title = p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells. | journal = Cancer Cytopathol | volume = 122 | issue = 10 | pages = 760-9 | month = Oct | year = 2014 | doi = 10.1002/cncy.21462 | PMID = 25069600 }}</ref> | *High grade [[urothelial carcinoma]] ~86% of cases.<ref name=pmid25069600>{{Cite journal | last1 = Piaton | first1 = E. | last2 = Casalegno | first2 = JS. | last3 = Advenier | first3 = AS. | last4 = Decaussin-Petrucci | first4 = M. | last5 = Mege-Lechevallier | first5 = F. | last6 = Ruffion | first6 = A. | last7 = Mekki | first7 = Y. | title = p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells. | journal = Cancer Cytopathol | volume = 122 | issue = 10 | pages = 760-9 | month = Oct | year = 2014 | doi = 10.1002/cncy.21462 | PMID = 25069600 }}</ref> | ||
===Negative=== | ===Negative=== | ||
*Breast carcinoma. | *Breast carcinoma. | ||
*Prostate carcinoma. | *[[Prostate carcinoma]]. | ||
*Lung squamous cell carcinoma.<ref name=pmid25069600/> | *[[Lung squamous cell carcinoma]].<ref name=pmid25069600/> | ||
==References== | ==References== | ||
Revision as of 18:51, 12 March 2015
p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.
Pattern
- Nuclear stain +/- cytoplasmic staining.
Use
- Squamous lesions of the uterine cervix - see HSIL.
- Head and neck squamous cell carcinoma, specifically human papillomavirus-associated head and neck squamous cell carcinoma.
Tumours
Positive
- Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC.
- High grade urothelial carcinoma ~86% of cases.[1]
Negative
- Breast carcinoma.
- Prostate carcinoma.
- Lung squamous cell carcinoma.[1]
References
- ↑ 1.0 1.1 Piaton, E.; Casalegno, JS.; Advenier, AS.; Decaussin-Petrucci, M.; Mege-Lechevallier, F.; Ruffion, A.; Mekki, Y. (Oct 2014). "p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.". Cancer Cytopathol 122 (10): 760-9. doi:10.1002/cncy.21462. PMID 25069600.