Difference between revisions of "Spironolactone bodies"

From Libre Pathology
Jump to navigation Jump to search
(create)
 
 
(4 intermediate revisions by 2 users not shown)
Line 1: Line 1:
'''Spironolactone bodies''' are seen in the context of long-term spironolcatone use.
'''Spironolactone bodies''' are seen in the cortex of the [[adrenal gland]] in the context of long-term spironolcatone use.


==General==
==General==
Line 6: Line 6:


Note:
Note:
*Spironolactone is a commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal  | last1 = Patel | first1 = KA. | last2 = Calomeni | first2 = EP. | last3 = Nadasdy | first3 = T. | last4 = Zynger | first4 = DL. | title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. | journal = Diagn Pathol | volume = 9 | issue = 1 | pages = 147 | month = Aug | year = 2014 | doi = 10.1186/1746-1596-9-147 | PMID = 25108298 }}</ref>
*Aldosterone antagonist.
*Commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal  | last1 = Patel | first1 = KA. | last2 = Calomeni | first2 = EP. | last3 = Nadasdy | first3 = T. | last4 = Zynger | first4 = DL. | title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. | journal = Diagn Pathol | volume = 9 | issue = 1 | pages = 147 | month = Aug | year = 2014 | doi = 10.1186/1746-1596-9-147 | PMID = 25108298 }}</ref>
*May be used to treat hypertension due to primary hyperaldosteronism related to adrenal pathology (nodular cortical hyperplasia or adenoma).
*Other uses include treatment of adult acne harnessing an antiandrogenic activity.


==Microscopic==
==Microscopic==
Line 17: Line 20:
Image:Spironolactone_bodies_high_mag.jpg | SB - high mag. (WC/Nephron)
Image:Spironolactone_bodies_high_mag.jpg | SB - high mag. (WC/Nephron)
Image:Spironolactone_bodies.png | SB (circled) - cropped high mag. (WC/Nephron)
Image:Spironolactone_bodies.png | SB (circled) - cropped high mag. (WC/Nephron)
Image:Adrenal CorticalAdenoma SpironolactoneBodies MP PA.JPG|Adrenal Cortical Adenoma - Spironolactone Bodies (SKB)
Image:Adrenal HyperplasticNodule SpironolactoneBodies MP PA.JPG|Adrenal Nodular Hyperplasia - Spironolactone Bodies (SKB)
</gallery>
</gallery>


==See also==
==See also==
*[[Adrenal gland]].
*[[Adrenal gland]].
*[[Drug reaction]].


==References==
==References==

Latest revision as of 11:59, 5 March 2015

Spironolactone bodies are seen in the cortex of the adrenal gland in the context of long-term spironolcatone use.

General

Etiology:

  • Long-term use of spironolactone.

Note:

  • Aldosterone antagonist.
  • Commonly used anti-hypertensive medication.[1]
  • May be used to treat hypertension due to primary hyperaldosteronism related to adrenal pathology (nodular cortical hyperplasia or adenoma).
  • Other uses include treatment of adult acne harnessing an antiandrogenic activity.

Microscopic

Features:[2]

  • Location: zona glomerulosa (where aldosterone is produced).
  • Appearance: eosinophilic spherical laminated whorls.

Images

See also

References

  1. Patel, KA.; Calomeni, EP.; Nadasdy, T.; Zynger, DL. (Aug 2014). "Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings.". Diagn Pathol 9 (1): 147. doi:10.1186/1746-1596-9-147. PMID 25108298.
  2. Kovacs K, Horvath E, Singer W (December 1973). "Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex". J. Clin. Pathol. 26 (12): 949-57. PMC 477936. PMID 4131694. http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=4131694.