Difference between revisions of "C-cell hyperplasia"
Jump to navigation
Jump to search
| Line 48: | Line 48: | ||
***Not in the isthmus. | ***Not in the isthmus. | ||
*Definitions vary.<ref>SR. 17 January 2011.</ref> | *Definitions vary.<ref>SR. 17 January 2011.</ref> | ||
*One definition - either of the following:<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | **One definition - either of the following:<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | ||
*#>50 C-cells per low-power field (x100). | **#>50 C-cells per low-power field (x100). | ||
*#*This part of the definition suffers from [[LPFitis]]. | **#*This part of the definition suffers from [[LPFitis]]. | ||
*#Confined to the thyroid gland and no larger than 10 mm in greatest dimension. | **#Confined to the thyroid gland and no larger than 10 mm in greatest dimension. | ||
*Another definition: | **Another definition: | ||
**Invasion of the basement membrane with stromal reaction. | ***Invasion of the basement membrane with stromal reaction. | ||
*A third definition: | **A third definition: | ||
**"Several clusters" of more than six C cells. | ***"Several clusters" of more than six C cells. | ||
===Images=== | ===Images=== | ||
Revision as of 17:49, 4 March 2015
| C-cell hyperplasia | |
|---|---|
| Diagnosis in short | |
| LM DDx | medullary thyroid carcinoma |
| Gross | not apparent |
| Site | thyroid gland |
|
| |
| Syndromes | Multiple endocrine neoplasia type 2A |
|
| |
| Prevalence | uncommon |
| Blood work | calcitonin level elevated |
| Prognosis | benign in itself |
| Treatment | prophylatic surgery |
C-cell hyperplasia is a pathology of the thyroid gland and considered the precursor for medullary thyroid carcinoma.
General
- Screening for C-cell hyperplasia/medullary thyroid carcinoma done with serum calcitonin level.[1]
- Associated with multiple endocrine neoplasia type 2A.[2]
Gross
- Not visible.
Microscopic
Features:
- Location:[4]
- Mid portion of lobe to upper third of lobe.
- Not at the poles.
- Not in the isthmus.
- Mid portion of lobe to upper third of lobe.
- Definitions vary.[5]
- One definition - either of the following:[1]
- >50 C-cells per low-power field (x100).
- This part of the definition suffers from LPFitis.
- Confined to the thyroid gland and no larger than 10 mm in greatest dimension.
- >50 C-cells per low-power field (x100).
- Another definition:
- Invasion of the basement membrane with stromal reaction.
- A third definition:
- "Several clusters" of more than six C cells.
- One definition - either of the following:[1]
Images
- CCH - crappy B&W image (nature.com).[6]
- CCH - crappy B&W image (nature.com).
- CCH (forpath.org).[7]
- CCH (unibas.ch).
- Nodular CCH (unibas.ch).
See also
References
- ↑ 1.0 1.1 Machens A, Hoffmann F, Sekulla C, Dralle H (December 2009). "Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer". Endocr. Relat. Cancer 16 (4): 1291–8. doi:10.1677/ERC-09-0136. PMID 19726541. http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291.
- ↑ Tyer, NM.; Braunstein, GD.; Frishberg, D.. "Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma.". Endocr Pract 17 (2): e4-7. doi:10.4158/EP10157.CR. PMID 21134882.
- ↑ Etit, D.; Faquin, WC.; Gaz, R.; Randolph, G.; DeLellis, RA.; Pilch, BZ. (Nov 2008). "Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases.". Arch Pathol Lab Med 132 (11): 1767-73. doi:10.1043/1543-2165-132.11.1767. PMID 18976013.
- ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf. Accessed on: 7 April 2012.
- ↑ SR. 17 January 2011.
- ↑ Guyétant, S.; Josselin, N.; Savagner, F.; Rohmer, V.; Michalak, S.; Saint-André, JP. (Aug 2003). "C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients.". Mod Pathol 16 (8): 756-63. doi:10.1097/01.MP.0000081727.75778.0C. PMID 12920219.
- ↑ URL: http://www.forpath.org/workshops/0201/html/case_7.asp. Accessed on: 21 May 2013.