Difference between revisions of "Uterine tumour resembling an ovarian sex cord stromal tumour"

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==Microscopic==
==Microscopic==
Features:
Features:
*Look like sex cord tumour:<ref>URL: [http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html]. Accessed on: 5 August 2010.</ref>
*Look like sex cord tumour:<ref name=pmid16118629>{{Cite journal  | last1 = Irving | first1 = JA. | last2 = Carinelli | first2 = S. | last3 = Prat | first3 = J. | title = Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 17-24 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800475 | PMID = 16118629 | URL = http://www.nature.com/modpathol/journal/v19/n1/full/3800475a.html }}</ref>
**May have: anastomosing cords, [[trabeculae]], small nests and/or tubules.
**May have: anastomosing cords, [[trabeculae]], small nests and/or tubules.


Notes:
Notes:
*May be subdivided into:<name=pmid25257516/>
*May be subdivided into:<ref name=pmid25257516/>
**Type 1 <50% sex cord-component (may be referred to as ''endometrial stromal tumour with sex cord-like elements''<ref name=pmid25150955/>).
**Type 1 <50% sex cord-component (may be referred to as ''endometrial stromal tumour with sex cord-like elements''<ref name=pmid25150955/>).
**Type 2 >50% sex cord-component.
**Type 2 >50% sex cord-component.

Latest revision as of 17:54, 23 February 2015

Uterine tumour resembling an ovarian sex cord stromal tumour, abbreviated UTROSCT, is a very rare uterine tumour.

General

  • Super rare.[1]
  • Typically postmenopausal - mean age ~ 52 years.[1]
  • Usually presentation is abnormal uterine bleeding.[1]
  • Prognosis good if tumour predominantly sex cord-like, i.e. Type 2.[1]

Microscopic

Features:

  • Look like sex cord tumour:[2]
    • May have: anastomosing cords, trabeculae, small nests and/or tubules.

Notes:

  • May be subdivided into:[3]
    • Type 1 <50% sex cord-component (may be referred to as endometrial stromal tumour with sex cord-like elements[1]).
    • Type 2 >50% sex cord-component.

DDx:

Images

IHC

Features:[3]

  • Calretinin +ve (sex cord-like component).
  • CD10 +ve (stroma).
  • PR +ve.
  • Inhibin +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Blake, EA.; Sheridan, TB.; Wang, KL.; Takiuchi, T.; Kodama, M.; Sawada, K.; Matsuo, K. (Oct 2014). "Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature.". Eur J Obstet Gynecol Reprod Biol 181: 163-70. doi:10.1016/j.ejogrb.2014.07.050. PMID 25150955.
  2. ↑ Irving, JA.; Carinelli, S.; Prat, J. (Jan 2006). "Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation.". Mod Pathol 19 (1): 17-24. doi:10.1038/modpathol.3800475. PMID 16118629.
  3. ↑ 3.0 3.1 Bakula-Zalewska, E.; Danska-Bidzinska, A.; Kowalewska, M.; Piascik, A.; Nasierowska-Guttmejer, A.; Bidzinski, M. (Dec 2014). "Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases.". Ann Diagn Pathol 18 (6): 329-32. doi:10.1016/j.anndiagpath.2014.08.009. PMID 25257516.
  4. ↑ Baker, P.; Oliva, E. (Mar 2007). "Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.". J Clin Pathol 60 (3): 235-43. doi:10.1136/jcp.2005.031203. PMID 17347285.
  5. ↑ Hashmi, AA.; Faridi, N.; Edhi, MM.; Khan, M. (2014). "Uterine tumor resembling ovarian sex cord tumor (UTROSCT), case report with literature review.". Int Arch Med 7 (1): 47. doi:10.1186/1755-7682-7-47. PMID 25395990.
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