Difference between revisions of "Tubulocystic carcinoma of the kidney"

From Libre Pathology
Jump to navigation Jump to search
m (+PaRCC)
Line 7: Line 7:
| Micro      = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
| Micro      = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
| Subtypes  =
| Subtypes  =
| LMDDx      = [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]
| LMDDx      = [[papillary renal cell carcinoma]], [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]
| Stains    =
| Stains    =
| IHC        = CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve
| IHC        = CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve
Line 43: Line 43:
*Males:Females ~ 7:1.<ref name=pmid19011562/>
*Males:Females ~ 7:1.<ref name=pmid19011562/>
*Prognosis - probably favourable.<ref name=pmid19011562/>
*Prognosis - probably favourable.<ref name=pmid19011562/>
*Thought to be related to [[papillary renal cell carcinoma]].<ref name=pmid19898225>{{Cite journal  | last1 = Zhou | first1 = M. | last2 = Yang | first2 = XJ. | last3 = Lopez | first3 = JI. | last4 = Shah | first4 = RB. | last5 = Hes | first5 = O. | last6 = Shen | first6 = SS. | last7 = Li | first7 = R. | last8 = Yang | first8 = Y. | last9 = Lin | first9 = F. | title = Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. | journal = Am J Surg Pathol | volume = 33 | issue = 12 | pages = 1840-9 | month = Dec | year = 2009 | doi = 10.1097/PAS.0b013e3181be22d1 | PMID = 19898225 }}</ref>


==Gross==
==Gross==
Line 56: Line 57:


DDx:
DDx:
*[[Papillary renal cell carcinoma]] (oncocytic variant).
*[[Renal oncocytoma]].  
*[[Renal oncocytoma]].  
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].

Revision as of 03:11, 13 February 2015

Tubulocystic carcinoma of the kidney
Diagnosis in short
Synonyms low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
LM cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
LM DDx papillary renal cell carcinoma, renal oncocytoma, cystic nephroma/mixed epithelial and stromal tumour, multilocular cystic renal cell carcinoma
IHC CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve
Gross multicystic lesion (bubble wrap-like appearance)
Site kidney
Clinical history typically male
Prevalence very rare
Prognosis good

Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.

It is also known as low-grade collecting duct carcinoma.[1]

In the Vancouver modification of the WHO classification of renal neoplasia, it is refered to as tubulocystic renal cell carcinoma (abbreviated TC-RCC).[2]

It should not be confused with collecting duct carcinoma, a very aggressive renal tumour.

General

Gross

  • Bubble wrap-like appearance - due to the cystic nature.[1][4]

Microscopic

Features:.[1]

  • Cysts of variable size lined by a single layer of epithelium that has a:
    • Cuboidal, flat, or hobnail morphology.
    • Eosinophilic cytoplasm.
    • Large nuclei with prominent nucleoli.
  • +/-Fibrotic stroma.

DDx:

Images

IHC

Features:[6]

  • CD10 +ve.
  • RCC +ve.
  • Vimentin +ve.
  • AMACR +ve.
  • CK7 -ve/+ve (focally in 2/3 tumours[7]).

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
  2. ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  3. ↑ Zhou, M.; Yang, XJ.; Lopez, JI.; Shah, RB.; Hes, O.; Shen, SS.; Li, R.; Yang, Y. et al. (Dec 2009). "Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification.". Am J Surg Pathol 33 (12): 1840-9. doi:10.1097/PAS.0b013e3181be22d1. PMID 19898225.
  4. ↑ Azoulay, S.; Vieillefond, A.; Paraf, F.; Pasquier, D.; Cussenot, O.; Callard, P.; Sibony, M. (Nov 2007). "Tubulocystic carcinoma of the kidney: a new entity among renal tumors.". Virchows Arch 451 (5): 905-9. doi:10.1007/s00428-007-0483-7. PMID 17786473.
  5. ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  6. ↑ Alexiev, BA.; Drachenberg, CB. (May 2013). "Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.". Virchows Arch 462 (5): 575-81. doi:10.1007/s00428-013-1398-0. PMID 23525677.
  7. ↑ Zhang, SH.; Shi, SF.; Huang, SF.; Zhang, YN.; Zheng, YY.; Chen, GY. (Aug 2012). "[Clinical and pathologic features of tubulocystic carcinoma of kidney].". Zhonghua Bing Li Xue Za Zhi 41 (8): 543-6. PMID 23157747.
Retrieved from "https://librepathology.org/w/index.php?title=Tubulocystic_carcinoma_of_the_kidney&oldid=36222"