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'''Lymphocytic interstitial pneumonia''' (abbreviated '''LIP'''), also known as '''lymphoid interstitial pneumonia''' and '''lymphocytic interstitial pneumonitis''', is an uncommon [[diffuse lung disease]]. | |||
==General== | |||
*Associated with autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]])<ref>URL: [http://emedicine.medscape.com/article/299643-overview http://emedicine.medscape.com/article/299643-overview]. Accessed on: 2 June 2010.</ref> and immunodeficiency.<ref name=pmid16088689>{{cite journal |author=Nicholson AG |title=Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung |journal=Semin Respir Crit Care Med |volume=22 |issue=4 |pages=409–22 |year=2001 |month=August |pmid=16088689 |doi=10.1055/s-2001-17384 |url=}}</ref> | |||
*Associated with viral infections ([[HIV]], EBV, human T-cell leukemia virus (HTLV) type 1). | |||
**Considered an AIDS-defining diagnosis.<ref>{{Cite journal | last1 = Turner | first1 = BJ. | last2 = Eppes | first2 = S. | last3 = McKee | first3 = LJ. | last4 = Cosler | first4 = L. | last5 = Markson | first5 = LE. | title = A population-based comparison of the clinical course of children and adults with AIDS. | journal = AIDS | volume = 9 | issue = 1 | pages = 65-72 | month = Jan | year = 1995 | doi = | PMID = 7893443 }}</ref> | |||
==Gross== | |||
*Location: basilar predominance. | |||
*Increased interstitial markings. | |||
==Microscopic== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/299643-diagnosis http://emedicine.medscape.com/article/299643-diagnosis]. Accessed on: 2 June 2010.</ref> | |||
*Small mature lymphocytes (usually B cells)<ref name=afip_vol2_265>AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.</ref> in the interstitium of the lung. | |||
*Plasma cells. | |||
*+/-Lymphoid follicles. | |||
Negatives: | |||
*No [[vasculitis]]. | |||
*No [[necrosis]]. | |||
Images: | |||
*[http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | |||
*[http://path.upmc.edu/cases/case176/micro.html LIP (upmc.edu)]. | |||
DDx: | |||
*[[Lymphoma]]. | |||
*Follicular bronchitis/bronchiolitis. | |||
*Nodular lymphoid hyperplasia. | |||
**This is determined in part by radiology; it has nodules radiographically. | |||
==Stains== | |||
To exclude infection:<ref>URL: [http://path.upmc.edu/cases/case176/dx.html http://path.upmc.edu/cases/case176/dx.html]. Accessed on: 8 January 2012.</ref> | |||
*[[GMS stain]] -ve. | |||
*[[Ziehl-Neelsen stain]] -ve. | |||
==IHC== | |||
*May be done to exclude lymphoma. | |||
==See also== | |||
*[[Diffuse lung diseases]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diffuse lung diseases]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||