Difference between revisions of "Tubulocystic carcinoma of the kidney"

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It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>
It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal  | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref>


In the Vancouver classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
In the [[Vancouver classification|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>


It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]].
It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]].


==General==
==General==
*Not in the WHO classification of renal tumours - as of 2013.<ref name=pmid23525677>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Drachenberg | first2 = CB. | title = Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study. | journal = Virchows Arch | volume = 462 | issue = 5 | pages = 575-81 | month = May | year = 2013 | doi = 10.1007/s00428-013-1398-0 | PMID = 23525677 }}</ref>
 
*Rare <1% - in a series of 615 cases.
*Rare <1% - in a series of 615 cases.
*Males:Females ~ 7:1.<ref name=pmid19011562/>
*Males:Females ~ 7:1.<ref name=pmid19011562/>
Line 45: Line 45:


==Gross==
==Gross==
*Bubble wrap-like appearance - due to the cystic nature.<ref name=pmid19011562/>
*Bubble wrap-like appearance - due to the cystic nature.<ref name=pmid19011562/><ref name=pmid17786473>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Vieillefond | first2 = A. | last3 = Paraf | first3 = F. | last4 = Pasquier | first4 = D. | last5 = Cussenot | first5 = O. | last6 = Callard | first6 = P. | last7 = Sibony | first7 = M. | title = Tubulocystic carcinoma of the kidney: a new entity among renal tumors. | journal = Virchows Arch | volume = 451 | issue = 5 | pages = 905-9 | month = Nov | year = 2007 | doi = 10.1007/s00428-007-0483-7 | PMID = 17786473 }}</ref>


==Microscopic==
==Microscopic==

Revision as of 06:20, 14 November 2014

Tubulocystic carcinoma of the kidney
Diagnosis in short
Synonyms low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
LM cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
LM DDx renal oncocytoma, cystic nephroma/mixed epithelial and stromal tumour, multilocular cystic renal cell carcinoma
IHC CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve
Gross multicystic lesion (bubble wrap-like appearance)
Site kidney
Clinical history typically male
Prevalence very rare
Prognosis good

Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.

It is also known as low-grade collecting duct carcinoma.[1]

In the Vancouver modification of the WHO classification of renal neoplasia, it is refered to as tubulocystic renal cell carcinoma (abbreviated TC-RCC).[2]

It should not be confused with collecting duct carcinoma, a very aggressive renal tumour.

General

  • Rare <1% - in a series of 615 cases.
  • Males:Females ~ 7:1.[1]
  • Prognosis - probably favourable.[1]

Gross

  • Bubble wrap-like appearance - due to the cystic nature.[1][3]

Microscopic

Features:.[1]

  • Cysts of variable size lined by a single layer of epithelium that has a:
    • Cuboidal, flat, or hobnail morphology.
    • Eosinophilic cytoplasm.
    • Large nuclei with prominent nucleoli.
  • +/-Fibrotic stroma.

DDx:

Images

IHC

Features:[5]

  • CD10 +ve.
  • RCC +ve.
  • Vimentin +ve.
  • AMACR +ve.
  • CK7 -ve/+ve (focally in 2/3 tumours[6]).

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
  2. ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  3. ↑ Azoulay, S.; Vieillefond, A.; Paraf, F.; Pasquier, D.; Cussenot, O.; Callard, P.; Sibony, M. (Nov 2007). "Tubulocystic carcinoma of the kidney: a new entity among renal tumors.". Virchows Arch 451 (5): 905-9. doi:10.1007/s00428-007-0483-7. PMID 17786473.
  4. ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  5. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid23525677
  6. ↑ Zhang, SH.; Shi, SF.; Huang, SF.; Zhang, YN.; Zheng, YY.; Chen, GY. (Aug 2012). "[Clinical and pathologic features of tubulocystic carcinoma of kidney].". Zhonghua Bing Li Xue Za Zhi 41 (8): 543-6. PMID 23157747.
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