Difference between revisions of "Olfactory neuroblastoma"
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==IHC== | ==IHC== | ||
* | *S-100: | ||
**Sustentacular cells +ve. | **Sustentacular cells +ve. | ||
**Small round cells -ve. | **Small round cells -ve. | ||
*Neuroendocrine markers +ve (CD56, synaptophysin). | *[[Neuroendocrine markers]] +ve (CD56, synaptophysin). | ||
Others: | Others: | ||
Revision as of 17:35, 13 September 2014
Olfactory neuroblastoma, also known as esthesioneuroblastoma, is a rare aggressive tumour of the head and neck.
Neuroblastoma is dealt with in the neuroblastoma article.
General
Epidemiology:[1]
- Prognosis: poor.
- Wide age range with bimodal distribution - teens and 60s.
- No sex predilection.
Clinical presentation:[1]
- Nasal obstruction ~ 70%.
- Epistaxis ~ 50%.
- Anosmia.
- Headache.
Gross
- Arises from olfactory mucosa - upper nasal cavity.[2]
Microscopic
Features:[1]
- Small round (blue) cell tumour with:
- Stippled chromatin.
- High NC ratio.
- +/-Flexner-Wintersteiner rosette - rosette with empty centre (donut hole).
- +/-Fibrillary, eosinophilic material (neuropil-like).[2]
DDx:
- Lymphoma.
- Small cell carcinoma.
- Other small round cell tumours.
- Basaloid squamous carcinoma.[citation needed]
Images:
IHC
- S-100:
- Sustentacular cells +ve.
- Small round cells -ve.
- Neuroendocrine markers +ve (CD56, synaptophysin).
Others:
See also
References
- ↑ 1.0 1.1 1.2 1.3 Thompson, LD. (Sep 2009). "Olfactory neuroblastoma.". Head Neck Pathol 3 (3): 252-9. doi:10.1007/s12105-009-0125-2. PMC 2811627. PMID 20596981. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/.
- ↑ 2.0 2.1 2.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 41. ISBN 978-0781765275.
- ↑ URL: http://path.upmc.edu/cases/case467.html. Accessed on: 21 January 2012.