Difference between revisions of "Tubulocystic carcinoma of the kidney"

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*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
*[[Multilocular cystic renal cell carcinoma]].
*[[Multilocular cystic renal cell carcinoma]].
===Images===
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref>
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f16.html#figure-title TCCK - high mag. (nature.com)].


==IHC==
==IHC==

Revision as of 21:07, 22 August 2014

Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.

It is also known as low-grade collecting duct carcinoma.[1]

General

  • Not in the WHO classification of renal tumours - as of 2013.[2]
  • Rare <1% - in a series of 615 cases.
  • Males:Females ~ 7:1.[1]
  • Prognosis - probably favourable.[1]

Gross

  • Bubble wrap-like appearance - due to the cystic nature.[1]

Microscopic

Features:.[1]

  • Cysts of variable size lined by a single layer of epithelium that has a:
    • Cuboidal, flat, or hobnail morphology.
    • Eosinophilic cytoplasm.
    • Large nuclei with prominent nucleoli.
  • +/-Fibrotic stroma.

DDx:

Images

IHC

Features:[2]

  • CD10 +ve.
  • RCC +ve.
  • Vimentin +ve.
  • AMACR +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
  2. ↑ 2.0 2.1 Alexiev, BA.; Drachenberg, CB. (May 2013). "Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.". Virchows Arch 462 (5): 575-81. doi:10.1007/s00428-013-1398-0. PMID 23525677.
  3. ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
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