Difference between revisions of "Gonadoblastoma"
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| Caption = Gondaloblastoma. [[H&E stain]]. | | Caption = Gondaloblastoma. [[H&E stain]]. | ||
| Micro = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]], | | Micro = immature germ cells (resembling Sertoli cells or granulosa cells),{{fact}} primitive germ cells resemble those of a [[dysgerminoma]], +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | ||
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | |||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[dysgerminoma]] | | LMDDx = [[dysgerminoma]], [[sex cord tumour with annular tubules]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = abnormal sexual development | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | ||
*Immature germ cells resembling Sertoli cells or granulosa cells. | *Immature germ cells resembling Sertoli cells or granulosa cells.{{fact}} | ||
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | **Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | ||
**Granulosa cells = form follicle-like structures. | **Granulosa cells = form follicle-like structures. | ||
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*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | *+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | ||
DDx: | |||
*[[Sex cord tumour with annular tubules]]. | |||
*[[Dysgerminoma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image:Gonadoblastoma - very low mag.jpg | Gonadoblastoma - very low mag. (WC/Nephron) | ||
Image: | Image:Gonadoblastoma - low mag.jpg | Gonadoblastoma - low mag. (WC/Nephron) | ||
Image:Gonadoblastoma - intermed mag.jpg | Gonadoblastoma - intermed mag. (WC/Nephron) | |||
Image:Gonadoblastoma - high mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
Image:Gonadoblastoma - b - high mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
Image:Gonadoblastoma - very high mag.jpg | Gonadoblastoma - very high mag. (WC/Nephron) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Germ cell tumours]] | |||
Latest revision as of 20:30, 15 July 2014
| Gonadoblastoma | |
|---|---|
| Diagnosis in short | |
 Gondaloblastoma. H&E stain. | |
|
| |
| LM | immature germ cells (resembling Sertoli cells or granulosa cells),[citation needed] primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. |
| LM DDx | dysgerminoma, sex cord tumour with annular tubules |
| Site | ovary |
|
| |
| Clinical history | abnormal sexual development |
| Prevalence | very rare |
Gonadoblastoma is a rare germ cell tumour with sex cord elements.
General
- Associated with abnormal sexual development.
- Often coexist with a dysgerminoma.
- A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.
Gross
- +/-Cystic.
Microscopic
Features:[1]
- Immature germ cells resembling Sertoli cells or granulosa cells.[citation needed]
- Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
- Granulosa cells = form follicle-like structures.
- May form nests.
- Primitive germ cells resemble those of a dysgerminoma.
- Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
- +/-Calcification (very common).
- +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.[2]
DDx:
Images
Gonadoblastoma - very low mag. (WC/Nephron)
Gonadoblastoma - low mag. (WC/Nephron)
Gonadoblastoma - intermed mag. (WC/Nephron)
Gonadoblastoma - high mag. (WC/Nephron)
Gonadoblastoma - high mag. (WC/Nephron)
Gonadoblastoma - very high mag. (WC/Nephron)
www:
- Gonadoblastoma - low mag. (webpathology.com).
- Gonadoblastoma - high mag. (webpathology.com).
- Gonadoblastoma - high mag. (webpathology.com).
- Gonadoblastoma - low mag. (flickr.com).
- Gonadoblastoma - intermed. mag. (flickr.com).
- Gonadoblastoma - high mag. (flickr.com).
- Gonadoblastoma - several cases (upmc.edu).
See also
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
- ↑ URL: http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/. Accessed on: 11 September 2011.