Gonadoblastoma: Difference between revisions
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| Caption = Gondaloblastoma. [[H&E stain]]. | | Caption = Gondaloblastoma. [[H&E stain]]. | ||
| Micro = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]], | | Micro = immature germ cells (resembling Sertoli cells or granulosa cells),{{fact}} primitive germ cells resemble those of a [[dysgerminoma]], +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | ||
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | |||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[dysgerminoma]] | | LMDDx = [[dysgerminoma]], [[sex cord tumour with annular tubules]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = abnormal sexual development | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | ||
*Immature germ cells resembling Sertoli cells or granulosa cells. | *Immature germ cells resembling Sertoli cells or granulosa cells.{{fact}} | ||
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | **Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | ||
**Granulosa cells = form follicle-like structures. | **Granulosa cells = form follicle-like structures. | ||
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*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | *+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | ||
DDx: | |||
*[[Sex cord tumour with annular tubules]]. | |||
*[[Dysgerminoma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image:Gonadoblastoma - very low mag.jpg | Gonadoblastoma - very low mag. (WC/Nephron) | ||
Image: | Image:Gonadoblastoma - low mag.jpg | Gonadoblastoma - low mag. (WC/Nephron) | ||
Image:Gonadoblastoma - intermed mag.jpg | Gonadoblastoma - intermed mag. (WC/Nephron) | |||
Image:Gonadoblastoma - high mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
Image:Gonadoblastoma - b - high mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
Image:Gonadoblastoma - very high mag.jpg | Gonadoblastoma - very high mag. (WC/Nephron) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Germ cell tumours]] | |||