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Difference between revisions of "Phosphaturic mesenchymal tumour, mixed connective tissue type"
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Phosphaturic mesenchymal tumour, mixed connective tissue type (view source)
Revision as of 19:55, 12 June 2014
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22927293/><ref name=pmid19828339/> | Features:<ref name=pmid22927293/><ref name=pmid19828339/> | ||
*Spindle cells without atypia | *Spindle cells without atypia and moderate lightly eosinophilic cytoplasm without distinctive cell borders. | ||
*Eosinophilic matrix - described as "gungy" (shabby).<ref name=pmid14707860/> | |||
*[[HPC-like vessels]]. | |||
*Osteoclast-type [[giant cell]]s. | *Osteoclast-type [[giant cell]]s. | ||
*+/-Hemorrhage. | |||
*+/-Calcifications. | *+/-Calcifications. | ||
DDx: | |||
*[[Osteosarcoma]]. | DDx:<ref name=pmid14707860/> | ||
*[[Osteosarcoma]] - has cellular atypia. | |||
*[[Hemangiopericytoma]]. | |||
*[[Giant cell tumour of bone]]. | |||
*[[Neurofibroma]]. | *[[Neurofibroma]]. | ||
*Other [[soft tissue lesions]]. | *Other [[soft tissue lesions]]. | ||
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*S-100 -ve. | *S-100 -ve. | ||
*CD34 -ve. | *CD34 -ve. | ||
*FGF-23 +ve.<ref name=pmid14707860>{{cite journal |author=Folpe AL, Fanburg-Smith JC, Billings SD, ''et al.'' |title=Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature |journal=Am. J. Surg. Pathol. |volume=28 |issue=1 |pages=1–30 |year=2004 |month=January |pmid=14707860 |doi= |url=}}</ref> | |||
Others:<ref name=pmid22035861>{{cite journal |author=Hu FK, Yuan F, Jiang CY, ''et al.'' |title=Tumor-induced osteomalacia with elevated fibroblast growth factor 23: a case of phosphaturic mesenchymal tumor mixed with connective tissue variants and review of the literature |journal=Chin J Cancer |volume=30 |issue=11 |pages=794–804 |year=2011 |month=November |pmid=22035861 |pmc=4013303 |doi=10.5732/cjc.011.10013 |url=}}</ref> | Others:<ref name=pmid22035861>{{cite journal |author=Hu FK, Yuan F, Jiang CY, ''et al.'' |title=Tumor-induced osteomalacia with elevated fibroblast growth factor 23: a case of phosphaturic mesenchymal tumor mixed with connective tissue variants and review of the literature |journal=Chin J Cancer |volume=30 |issue=11 |pages=794–804 |year=2011 |month=November |pmid=22035861 |pmc=4013303 |doi=10.5732/cjc.011.10013 |url=}}</ref> | ||