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Difference between revisions of "Seminal vesicles"
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The '''seminal vesicles''' are a pair of organs closely associated with the [[prostate gland]] that fluid to the ejaculate. They are seen attached to prostatectomy specimens. | |||
==General== | |||
*Seen in radical prostatectomies and occasionally in core biopsies. | |||
*Very rarely a site of a [[primary seminal vesicle carcinoma|primary cancer]]. | |||
==Microscopic== | |||
*Fern-like architecture - epithelial component clustered closely, looks like it connects. | |||
**Epithelium surrounded by a thick layer of muscle (>10 cells across ~80 microns). | |||
*Lipofuscin (coarse cytoplasmic yellow granules approximately 1-2 micrometers) - '''key feature'''. | |||
*Nucleoli - common. | |||
*Nuclear inclusions - common.<ref>URL: [http://surgpathcriteria.stanford.edu/prostate/adenocarcinoma/benign-vs-carcinoma.html http://surgpathcriteria.stanford.edu/prostate/adenocarcinoma/benign-vs-carcinoma.html]. Accessed on: 10 January 2013.</ref> | |||
Notes: | |||
*The ''ejaculatory ducts'' have the same epithelium as the seminal vesicles.<ref name=pmid12657938>{{cite journal |author=Leroy X, Ballereau C, Villers A, ''et al.'' |title=MUC6 is a marker of seminal vesicle-ejaculatory duct epithelium and is useful for the differential diagnosis with prostate adenocarcinoma |journal=Am. J. Surg. Pathol. |volume=27 |issue=4 |pages=519–21 |year=2003 |month=April |pmid=12657938 |doi= |url=}}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Seminal_vesicle_low_mag.jpg | SV - showing fern-like architecture. (WC/Nephron) | |||
Image:Seminal_vesicle_high_mag.jpg | SV - looking vaguely like to prostate adenocarcinoma. (WC/Nephron) | |||
Image:Seminal_vesicle_intermed_mag.jpg | SV - looks a bit like prostate but lumina too big. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://dspace.udel.edu:8080/dspace/bitstream/19716/2016/1/cmrsvlm3.GIF SV (udel.edu)]. | |||
==IHC== | |||
*PSA -ve.<ref name=pmid22895132>{{Cite journal | last1 = Itami | first1 = Y. | last2 = Nagai | first2 = Y. | last3 = Kobayashi | first3 = Y. | last4 = Shimizu | first4 = N. | last5 = Yamamoto | first5 = Y. | last6 = Minami | first6 = T. | last7 = Hayashi | first7 = T. | last8 = Nozawa | first8 = M. | last9 = Yoshimura | first9 = K. | title = [A case of prostatic cancer with a low PSA level accompanied with cystic formation requiring differentiation from adenocarcinoma of the seminal vesicle]. | journal = Hinyokika Kiyo | volume = 58 | issue = 7 | pages = 349-53 | month = Jul | year = 2012 | doi = | PMID = 22895132 }}</ref> | |||
*CK7 +ve.<ref name=pmid19468449>{{Cite journal | last1 = Tarján | first1 = M. | last2 = Ottlecz | first2 = I. | last3 = Tot | first3 = T. | title = Primary adenocarcinoma of the seminal vesicle. | journal = Indian J Urol | volume = 25 | issue = 1 | pages = 143-5 | month = Jan | year = 2009 | doi = 10.4103/0970-1591.45557 | PMID = 19468449 }}</ref><ref name=pmid22076175>{{Cite journal | last1 = Terada | first1 = T. | title = Monstrous epithelial cell clusters in the seminal vesicle. | journal = Int J Clin Exp Pathol | volume = 4 | issue = 7 | pages = 727-30 | month = | year = 2011 | doi = | PMID = 22076175 }}</ref> | |||
*[[CK20]] -ve.<ref name=pmid19468449/> | |||
*p63 +ve.<ref name=pmid22076175/> | |||
*CK34betaE12 -ve.<ref name=pmid22076175/> | |||
*AMACR -ve.<ref name=pmid22076175/> | |||
==Sign out== | |||
<pre> | |||
B. PROSTATE, RIGHT MEDIAL SUPERIOR, BIOPSY: | |||
- BENIGN PROSTATE TISSUE. | |||
- BENIGN SEMINAL VESICLE/EJACULATORY DUCT. | |||
</pre> | |||
==See also== | |||
*[[Prostate gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Genitourinary pathology]] | |||