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Secretory carcinoma of the breast (view source)
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'''Secretory carcinoma of the breast''' is an uncommon form of [[invasive breast cancer]] that has an appearance similar to ''[[breast with secretory changes]]''. | |||
It is also known as '''secretory breast carcinoma''', abbreviated '''SBC'''. | |||
==General== | |||
*Favourable prognosis.<ref name=pmid22129193>{{Cite journal | last1 = Vasudev | first1 = P. | last2 = Onuma | first2 = K. | title = Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1606-10 | month = Dec | year = 2011 | doi = 10.5858/arpa.2010-0351-RS | PMID = 22129193 }}</ref> | |||
*Children and adults. | |||
==Microscopic== | |||
Features:<ref name=pmid19011601>{{Cite journal | last1 = Laé | first1 = M. | last2 = Fréneaux | first2 = P. | last3 = Sastre-Garau | first3 = X. | last4 = Chouchane | first4 = O. | last5 = Sigal-Zafrani | first5 = B. | last6 = Vincent-Salomon | first6 = A. | title = Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. | journal = Mod Pathol | volume = 22 | issue = 2 | pages = 291-8 | month = Feb | year = 2009 | doi = 10.1038/modpathol.2008.184 | PMID = 19011601 | URL = http://www.nature.com/modpathol/journal/v22/n2/full/modpathol2008184a.html }}</ref> | |||
*Abundant cytoplasm with fine vacuolation - clear/pale or amphophilic. | |||
*Mitoses - uncommon. | |||
*Nucleoli - rare. | |||
*Architecture: solid, papillary, cribriform or microcystic. | |||
DDx: | |||
*[[Lactational change]]<ref name=pmid9684599>{{Cite journal | last1 = Vesoulis | first1 = Z. | last2 = Kashkari | first2 = S. | title = Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report. | journal = Acta Cytol | volume = 42 | issue = 4 | pages = 1032-6 | month = | year = | doi = | PMID = 9684599 }}</ref> - glandular architecture. | |||
===Images=== | |||
*[http://www.webpathology.com/image.asp?n=1&Case=300 Secretory breast carcinoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=300 Secretory breast carcinoma - high mag. (webpathology.com)]. | |||
*[http://www.nature.com/modpathol/journal/v22/n2/fig_tab/modpathol2008184f1.html#figure-title Secretory breast carcinoma (nature.com)]. | |||
==IHC== | |||
Triple negative (ER -ve, PR -ve, HER2 -ve).<ref name=pmid22129193>{{Cite journal | last1 = Vasudev | first1 = P. | last2 = Onuma | first2 = K. | title = Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1606-10 | month = Dec | year = 2011 | doi = 10.5858/arpa.2010-0351-RS | PMID = 22129193 }}</ref> | |||
Others: | |||
*Alpha-lactalbumin +ve. | |||
*S-100 protein +ve. | |||
*Polyclonal CEA +ve. | |||
==Molecular pathology== | |||
Characteristic translocation:<ref name=pmid22129193/> | |||
*t(12;15). | |||
**ETV6-NTRK3. | |||
Note: | |||
*This translocation is also seen in [[mammary analogue secretory carcinoma]]<ref name=pmid20410810>{{Cite journal | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref> and [[congenital-infantile fibrosarcoma]]. | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Invasive breast cancer]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||