Difference between revisions of "Invasive lobular carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Lobular_carcinoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Lobular carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[invasive ductal carcinoma of the breast]] with lobular features, poorly differentiated carcinoma, [[LCIS]] | |||
| Stains = | |||
| IHC = usu. ER and PR +ve, HER2 -ve, CK7 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = relatively common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = other breast tumours | |||
| Tx = | |||
}} | |||
'''Invasive lobular carcinoma''', abbreviated '''ILC''', is the second most common form of [[Invasive breast cancer]]. | '''Invasive lobular carcinoma''', abbreviated '''ILC''', is the second most common form of [[Invasive breast cancer]]. | ||
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*Commonly have low grade nuclear features. | *Commonly have low grade nuclear features. | ||
DDx: | |||
*[[Invasive ductal carcinoma of the breast]] with lobular features. | *[[Invasive ductal carcinoma of the breast]] with lobular features. | ||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
*[[LCIS]]. | |||
===Images=== | ===Images=== | ||
Revision as of 10:45, 14 February 2014
| Invasive lobular carcinoma | |
|---|---|
| Diagnosis in short | |
 Lobular carcinoma. H&E stain. | |
| LM DDx | invasive ductal carcinoma of the breast with lobular features, poorly differentiated carcinoma, LCIS |
| IHC | usu. ER and PR +ve, HER2 -ve, CK7 +ve |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | relatively common |
| Clin. DDx | other breast tumours |
Invasive lobular carcinoma, abbreviated ILC, is the second most common form of Invasive breast cancer.
It may be referred to as lobular carcinoma; however, this may lead to confusion with lobular carcinoma in situ.
General
Microscopic
Features:
- "Single file" - cell line-up in a row.
- Cell should not be cohesive -- lymphoma should briefly come to mind.
- primary lymphoma of the breast exists... but it is extremely rare.
- Cell should not be cohesive -- lymphoma should briefly come to mind.
- NO gland formation.
- If it forms glands... it is more likely NST.
- May have signet ring morphology.
- NO desmoplastic reaction, i.e. the stroma surrounding the tumour cells should look benign and undisturbed.
Note:
- Commonly have low grade nuclear features.
DDx:
- Invasive ductal carcinoma of the breast with lobular features.
- Poorly differentiated carcinoma.
- LCIS.
Images
Lobular carcinoma - low mag. (WC/Nephron)
Lobular carcinoma - high mag. (WC/Nephron)
Lobular carcinoma - very high mag. (WC/Nephron)
More WC images:
Subclassification
- Classic lobular carcinoma.
- Low nuclear grade - NO significant variation of nucleus size.
- Pleomorphic lobular carcinoma.
- Significant nuclear atypia.
Note:
- Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."[3]
See also
References
- ↑ URL: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006. Accessed on: 19 April 2011.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 192090
- ↑ MUA. Jan 22, 2009.