Difference between revisions of "Mucinous breast carcinoma"

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#redirect [[Invasive_breast_cancer#Mucinous_breast_carcinoma]]
'''Mucinous breast carcinoma''' is an uncommon form of breast cancer that has a good prognosis compared to the common [[invasive ductal carcioma of the breast|ductal carcinoma]].
 
It is also known as '''mucinous carcinoma of the breast''', and '''colloid carcinoma of the breast'''.
 
==General==
*Rare.
*Good prognosis.<ref name=pmid18809061>{{Cite journal  | last1 = Barkley | first1 = CR. | last2 = Ligibel | first2 = JA. | last3 = Wong | first3 = JS. | last4 = Lipsitz | first4 = S. | last5 = Smith | first5 = BL. | last6 = Golshan | first6 = M. | title = Mucinous breast carcinoma: a large contemporary series. | journal = Am J Surg | volume = 196 | issue = 4 | pages = 549-51 | month = Oct | year = 2008 | doi = 10.1016/j.amjsurg.2008.06.013 | PMID = 18809061 }}</ref>
*Usually older women.
 
==Gross==
*Pale, glistening, jelly-like appearance.
*Well-circumscribed.
 
Image:
*[http://www.webpathology.com/image.asp?case=297&n=1 Mucinous carcinoma of the breast (webpathology.com)].
 
==Microscopic==
Features:
*Malignant mucin producing glands.
**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal  | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month =  | year =  | doi =  | PMID = 22006768 }}</ref>
**Cells should float in the mucin - '''key feature'''.
**Glands typically have irregular edges.
**+/-Vessels within the mucin pools.
 
DDx:
*[[DCIS]] with a mucinous component.
**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.
 
Note:
*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site.
*All mucinous lesions should be excised.<ref name=pmid12218567>{{Cite journal  | last1 = Jacobs | first1 = TW. | last2 = Connolly | first2 = JL. | last3 = Schnitt | first3 = SJ. | title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? | journal = Am J Surg Pathol | volume = 26 | issue = 9 | pages = 1095-110 | month = Sep | year = 2002 | doi =  | PMID = 12218567 }}</ref>
 
==IHC==
*ER +ve.
*PR +ve.
*HER2 -ve.
 
==See also==
*[[Invasive breast cancer]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Invasive breast cancer]]

Revision as of 09:48, 14 February 2014

Mucinous breast carcinoma is an uncommon form of breast cancer that has a good prognosis compared to the common ductal carcinoma.

It is also known as mucinous carcinoma of the breast, and colloid carcinoma of the breast.

General

  • Rare.
  • Good prognosis.[1]
  • Usually older women.

Gross

  • Pale, glistening, jelly-like appearance.
  • Well-circumscribed.

Image:

Microscopic

Features:

  • Malignant mucin producing glands.
    • Mucinous component must comprise >90% of the tumour - required for diagnosis.[2]
    • Cells should float in the mucin - key feature.
    • Glands typically have irregular edges.
    • +/-Vessels within the mucin pools.

DDx:

  • DCIS with a mucinous component.
    • Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.

Note:

  • The amount of mucinous component to call mucinous carcinoma varies by anatomical site.
  • All mucinous lesions should be excised.[3]

IHC

  • ER +ve.
  • PR +ve.
  • HER2 -ve.

See also

References

  1. ↑ Barkley, CR.; Ligibel, JA.; Wong, JS.; Lipsitz, S.; Smith, BL.; Golshan, M. (Oct 2008). "Mucinous breast carcinoma: a large contemporary series.". Am J Surg 196 (4): 549-51. doi:10.1016/j.amjsurg.2008.06.013. PMID 18809061.
  2. ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
  3. ↑ Jacobs, TW.; Connolly, JL.; Schnitt, SJ. (Sep 2002). "Nonmalignant lesions in breast core needle biopsies: to excise or not to excise?". Am J Surg Pathol 26 (9): 1095-110. PMID 12218567.
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