Difference between revisions of "Fetal thrombotic vasculopathy"
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'''Fetal thrombotic vasculopathy''', abbreviated ''FTV'', is characterized by thrombi in the fetus. In the context of a [[placenta]], it is thrombi in the fetal [[blood vessel]]s of the placenta. | |||
A large number of terms are used for this including:<ref name=pmid19237859>{{Cite journal | last1 = Marchetti | first1 = D. | last2 = Belviso | first2 = M. | last3 = Fulcheri | first3 = E. | title = A case of stillbirth: the importance of placental investigation in medico-legal practice. | journal = Am J Forensic Med Pathol | volume = 30 | issue = 1 | pages = 64-8 | month = Mar | year = 2009 | doi = 10.1097/PAF.0b013e318187387e | PMID = 19237859 }}</ref> | |||
*''Fibrinous vasculosis''. | |||
*''Fibromuscular sclerosis''. | |||
*''Fetal artery stem thrombosis''. | |||
The multitude of terms reflects the confusion about this finding and that it has numerous etiologies.<ref name=pmid19237859/> | |||
==General== | |||
*May cause [[IUGR]]. | |||
*Associated with cerebral palsy and common in perinatal deaths.<ref name=pmid10414494>{{cite journal |author=Kraus FT, Acheen VI |title=Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy |journal=Hum. Pathol. |volume=30 |issue=7 |pages=759–69 |year=1999 |month=July |pmid=10414494 |doi= |url=}}</ref> | |||
*Mother may have a prothrombotic condition.<ref name=pmid24108664>{{Cite journal | last1 = Magnetti | first1 = F. | last2 = Bagna | first2 = R. | last3 = Botta | first3 = G. | last4 = Viano | first4 = A. | last5 = Dorati | first5 = G. | last6 = Raia | first6 = M. | last7 = Bertino | first7 = E. | last8 = Saracco | first8 = P. | title = Fetal Thrombotic Vasculopathy and Perinatal Thrombosis: Should all Placentas be Examined? | journal = Am J Perinatol | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1055/s-0033-1357267 | PMID = 24108664 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid10414494>{{Cite journal | last1 = Kraus | first1 = FT. | last2 = Acheen | first2 = VI. | title = Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 759-69 | month = Jul | year = 1999 | doi = | PMID = 10414494 }}</ref> | |||
*Thrombus in the fetal vasculature +/- recanalization. | |||
**Eosinophilic (light pink on H&E), moderately granular intravascular material (fibrin) with layering. | |||
*Clustered fibrotic villi without blood vessels - '''key feature'''. | |||
**This is a chronic change. | |||
===Images=== | |||
www: | |||
*[http://jcp.bmj.com/content/61/12/1254/F8.large.jpg FTV (bmj.com)].<ref>URL: [http://jcp.bmj.com/content/61/12/1254.abstract http://jcp.bmj.com/content/61/12/1254.abstract]. Accessed on: 12 January 2011.</ref> | |||
*[http://gut.bmj.com/content/41/3/354/F3.large.jpg Thrombus - rat (bmj.com)].<ref>URL: [http://gut.bmj.com/content/41/3/354.full http://gut.bmj.com/content/41/3/354.full]. Accessed on: 12 January 2011.</ref> | |||
*[http://www.womenandinfants.org/fertilityandpregnancy/images/FTV.Fig.4a.jpg FTV - low mag. (womenandinfants.org)].<ref>URL: [http://www.womenandinfants.org/fertilityandpregnancy/current-topics-in-perinatal-pathology.cfm http://www.womenandinfants.org/fertilityandpregnancy/current-topics-in-perinatal-pathology.cfm]. Accessed on: 17 December 2012.</ref> | |||
*[http://www.womenandinfants.org/fertilityandpregnancy/images/FTV.Fig.4b.jpg FTV - high mag. (womenandinfants.org)]. | |||
<gallery> | |||
Image:Fetal_thrombotic_vasculopathy_-_intermed_mag.jpg | FTV - intermed. mag. (WC) | |||
Image:Fetal_thrombotic_vasculopathy_-_high_mag.jpg | FTV - high mag. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH: | |||
- FETAL THROMBOTIC VASCULOPATHY, SEE COMMENT. | |||
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI INCREASED PERIVILLOUS FIBRIN DEPOSITION | |||
AND CALCIFICATIONS. | |||
- PLACENTAL INFARCT (1.5 CM IN MAXIMAL DIMENSION). | |||
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS. | |||
- FETAL MEMBRANES WITHIN NORMAL LIMITS. | |||
COMMENT: | |||
Mother and baby should be worked up for prothrombotic conditions. | |||
</pre> | |||
==See also== | |||
*[[Placenta]]. | |||
*[[Systemic lupus erythematosus]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Placenta]] | |||
Revision as of 02:16, 22 January 2014
Fetal thrombotic vasculopathy, abbreviated FTV, is characterized by thrombi in the fetus. In the context of a placenta, it is thrombi in the fetal blood vessels of the placenta.
A large number of terms are used for this including:[1]
- Fibrinous vasculosis.
- Fibromuscular sclerosis.
- Fetal artery stem thrombosis.
The multitude of terms reflects the confusion about this finding and that it has numerous etiologies.[1]
General
- May cause IUGR.
- Associated with cerebral palsy and common in perinatal deaths.[2]
- Mother may have a prothrombotic condition.[3]
Microscopic
Features:[2]
- Thrombus in the fetal vasculature +/- recanalization.
- Eosinophilic (light pink on H&E), moderately granular intravascular material (fibrin) with layering.
- Clustered fibrotic villi without blood vessels - key feature.
- This is a chronic change.
Images
www:
- FTV (bmj.com).[4]
- Thrombus - rat (bmj.com).[5]
- FTV - low mag. (womenandinfants.org).[6]
- FTV - high mag. (womenandinfants.org).
FTV - intermed. mag. (WC)
FTV - high mag. (WC)
Sign out
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH: - FETAL THROMBOTIC VASCULOPATHY, SEE COMMENT. - PLACENTAL DISC WITH THIRD TRIMESTER VILLI INCREASED PERIVILLOUS FIBRIN DEPOSITION AND CALCIFICATIONS. - PLACENTAL INFARCT (1.5 CM IN MAXIMAL DIMENSION). - THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS. - FETAL MEMBRANES WITHIN NORMAL LIMITS. COMMENT: Mother and baby should be worked up for prothrombotic conditions.
See also
References
- ↑ 1.0 1.1 Marchetti, D.; Belviso, M.; Fulcheri, E. (Mar 2009). "A case of stillbirth: the importance of placental investigation in medico-legal practice.". Am J Forensic Med Pathol 30 (1): 64-8. doi:10.1097/PAF.0b013e318187387e. PMID 19237859.
- ↑ 2.0 2.1 Kraus FT, Acheen VI (July 1999). "Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy". Hum. Pathol. 30 (7): 759–69. PMID 10414494. Cite error: Invalid
<ref>tag; name "pmid10414494" defined multiple times with different content - ↑ Magnetti, F.; Bagna, R.; Botta, G.; Viano, A.; Dorati, G.; Raia, M.; Bertino, E.; Saracco, P. (Oct 2013). "Fetal Thrombotic Vasculopathy and Perinatal Thrombosis: Should all Placentas be Examined?". Am J Perinatol. doi:10.1055/s-0033-1357267. PMID 24108664.
- ↑ URL: http://jcp.bmj.com/content/61/12/1254.abstract. Accessed on: 12 January 2011.
- ↑ URL: http://gut.bmj.com/content/41/3/354.full. Accessed on: 12 January 2011.
- ↑ URL: http://www.womenandinfants.org/fertilityandpregnancy/current-topics-in-perinatal-pathology.cfm. Accessed on: 17 December 2012.