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| *Abbreviated ''MGH''. | | *Abbreviated ''MGH''. |
| *[[AKA]] ''microglandular change''. | | *[[AKA]] ''microglandular change''. |
| ===General===
| | {{Main|Microglandular hyperplasia}} |
| *Associated with [[OCP]] use.<ref name=pmid10757337>{{Cite journal | last1 = Zaino | first1 = RJ. | title = Glandular lesions of the uterine cervix. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 261-74 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880047 | PMID = 10757337 | URL = http://www.nature.com/modpathol/journal/v13/n3/full/3880047a.html }}</ref>
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| *May be confused with adenocarcinoma.<ref name=pmid7234352>{{Cite journal | last1 = Jobo | first1 = T. | last2 = Kuramoto | first2 = H. | last3 = Morisawa | first3 = T. | title = [Microglandular hyperplasia of the cervix: reevaluation of the polyp (author's transl)]. | journal = Acta Obstet Gynaecol Jpn | volume = 33 | issue = 5 | pages = 651-8 | month = May | year = 1981 | doi = | PMID = 7234352 }}</ref>
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| ===Gross===
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| Features:
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| *Yellowish polypoid/papillary lesion.<ref name=cxhealth>URL: [http://www.cervicalhealth.com/colposcopy.php http://www.cervicalhealth.com/colposcopy.php]. Accessed on: 18 December 2013.</ref><ref name=pmid7234352/>
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| Images:
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| *[http://www.cervicalhealth.com/colposcopy.php MGH at colposcopy (cervicalhealth.com)].<ref name=cxhealth/>
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| ===Microscopic===
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| Features:<ref name=pmid10757337/>
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| *Cytologically benign - '''important'''.
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| **Usually cuboidal morphology.
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| **Typically clear cytoplasm.
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| *Crowded small glands (classic), reticular or solid.
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| Significant negatives:
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| *Nuclear atypia absent.
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| *[[NC ratio]] not significantly increased.
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| DDx:
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| *[[Endocervical adenocarcinoma in situ|Adenocarcinoma in situ of the uterine cervix]].
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| *Endometrial mucinous microglandular adenocarcinoma - very rare.<ref name=pmid16306789>{{Cite journal | last1 = Giordano | first1 = G. | last2 = D'Adda | first2 = T. | last3 = Gnetti | first3 = L. | last4 = Merisio | first4 = C. | last5 = Melpignano | first5 = M. | title = Endometrial mucinous microglandular adenocarcinoma: morphologic, immunohistochemical features, and emphasis in the human papillomavirus status. | journal = Int J Gynecol Pathol | volume = 25 | issue = 1 | pages = 77-82 | month = Jan | year = 2006 | doi = | PMID = 16306789 }}</ref><ref name=pmid12808571>{{Cite journal | last1 = Zamecnik | first1 = M. | last2 = Skalova | first2 = A. | last3 = Opatrny | first3 = V. | title = Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasia. | journal = Ann Diagn Pathol | volume = 7 | issue = 3 | pages = 180-6 | month = Jun | year = 2003 | doi = | PMID = 12808571 }}</ref>
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| *[[Clear cell carcinoma of the uterine cervix]].<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref>
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| Images:
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| *[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)].
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| *[http://sunnybrook.ca/uploads/cx_MGH_5_vd.jpg MGH (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro]. Accessed on: 25 February 2012.</ref>
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| ===IHC===
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| Features:<ref name=pmid12819393>{{Cite journal | last1 = Qiu | first1 = W. | last2 = Mittal | first2 = K. | title = Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium. | journal = Int J Gynecol Pathol | volume = 22 | issue = 3 | pages = 261-5 | month = Jul | year = 2003 | doi = 10.1097/01.PGP.0000071043.12278.8D | PMID = 12819393 }}</ref>
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| *Ki-67 ~ 0.5% cells.
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| *Vimentin -ve.
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| *PR +ve ~ 60% of cases.
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| *ER +ve/-ve.
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| Others:<ref name=pmid12819393/>
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| *p53 -ve.
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| *CEA -ve.
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| *p16 -ve (scattered cells +ve).{{fact}}
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| ===Sign out===
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| <pre>
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| UTERINE ENDOCERVIX, CURETTAGE:
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| - MICROGLANDULAR HYPERPLASIA.
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| - SQUAMOUS EPITHELIUM WITH REACTIVE CHANGES AND METAPLASTIC CHANGES.
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| </pre>
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| ====Micro====
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| The sections show gland forming epithelium without nuclear atypia (no nuclear membrane
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| irregularities, no coarse chromatin). The nuclei are less than 2x the size of a neutrophil,
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| regularly spaced, pale staining and have small regular nucleoli visible with the 20x
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| objective. No mitotic activity is apparent.
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| Fragments of reactive squamous epithelium with metaplastic changes are present. Benign
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| superficial squamous epithelium is identified.
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|
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|
| ==Wolffian duct hyperplasia== | | ==Wolffian duct hyperplasia== |