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Difference between revisions of "Cat scratch disease"
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| Caption = Cat scratch disease. [[H&E stain]]. | | Caption = Cat scratch disease. [[H&E stain]]. | ||
| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with B. henselae | | Micro = necrotizing granulomas with neutrophils and star-shaped (stellate, +/-multinucleated giant cells, microorganisms consistent with ''B. henselae'' | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]] | | LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]] | ||
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==General== | ==General== | ||
*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal | last1 = Jerris | first1 = RC. | last2 = Regnery | first2 = RL. | title = Will the real agent of cat-scratch disease please stand up? | journal = Annu Rev Microbiol | volume = 50 | issue = | pages = 707-25 | month = | year = 1996 | doi = 10.1146/annurev.micro.50.1.707 | PMID = 8905096 }}</ref> a gram-negative | *Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal | last1 = Jerris | first1 = RC. | last2 = Regnery | first2 = RL. | title = Will the real agent of cat-scratch disease please stand up? | journal = Annu Rev Microbiol | volume = 50 | issue = | pages = 707-25 | month = | year = 1996 | doi = 10.1146/annurev.micro.50.1.707 | PMID = 8905096 }}</ref> a gram-negative bacillus (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP|110}}</ref> | ||
*Treatment: antibiotics. | *Treatment: antibiotics. | ||
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***Microabscesses often described as "stellate" (star-shaped). | ***Microabscesses often described as "stellate" (star-shaped). | ||
*+/-Multinucleated giant cells. | *+/-Multinucleated giant cells. | ||
*Microorganism consistent with ''B. henselae''. | |||
Notes: | Notes: | ||
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==Stains== | ==Stains== | ||
*Warthin-Starry stain +ve. | *Warthin-Starry stain +ve -- bacilli. | ||
*Gram stain -ve. | |||
==IHC== | ==IHC== | ||
*B. henselae IHC stain +ve - '''diagnostic'''. | *B. henselae IHC stain +ve -- bacilli - '''diagnostic'''. | ||
==See also== | ==See also== | ||