Difference between revisions of "Leydig cell tumour"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Leydig_cell_tumour2.jpg
| Width      =
| Caption    = Leydig cell tumour. [[H&E stain]].
| Micro      = cytoplasmic vacuolization, cytoplasm - clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid - eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei
| Subtypes  =
| LMDDx      = [[spermatocytic seminoma]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]]
| Stains    =
| IHC        = inhibin-alpha +ve, calretinin +ve, melan A +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = solid, red/tan
| Grossing  =
| Site      = [[testis]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  = +/-elevated testosterone
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other testicular tumours
}}
'''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]].
'''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]].
''Interstitial cell tumour'' should '''not''' be confused with ''[[Renomedullary interstitial cell tumour]]''.


==General==
==General==
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==IHC==
==IHC==
*Inhibin-alpha.
*Inhibin-alpha +ve.
*Calretinin.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref>
*Calretinin +ve.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref>
*Melan A.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref>
*Melan A +ve.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref>
**AKA ''MART-1''.
**[[AKA]] ''MART-1''.
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours.
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours.



Revision as of 04:12, 18 November 2013

Leydig cell tumour
Diagnosis in short

Leydig cell tumour. H&E stain.

LM cytoplasmic vacuolization, cytoplasm - clear to eosinophilic, +/-Reinke crystals (cylindrical crystalloid - eosinophilic cytoplasmic bodies), +/-nucleoli common, round nuclei
LM DDx spermatocytic seminoma (testis only), pregnancy luteoma (females only), Sertoli-Leydig cell tumour
IHC inhibin-alpha +ve, calretinin +ve, melan A +ve
Gross solid, red/tan
Site testis

Prevalence uncommon
Blood work +/-elevated testosterone
Prognosis benign
Clin. DDx other testicular tumours

Leydig cell tumour, also known as interstitial cell tumour, is an uncommon benign sex cord-stromal tumour, typically seen in the testis.


Interstitial cell tumour should not be confused with Renomedullary interstitial cell tumour.

General

  • Arises from the interstitial cell.
  • May be associated with increased testosterone.

Gross

  • Solid, lobulated.
  • Red/tan.

Image:

Microscopic

Features:[1]

  • Vacuolization (cytoplasm) - key feature.
  • Cytoplasm - clear to eosinophilic - important.
  • Reinke crystals - classic finding, usually not present.
    • Cylindrical crystalloid eosinophilic cytoplasmic bodies.
  • Nucleoli common.
  • Round nuclei.

DDx:

Images

www:

IHC

See also

References

  1. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 581. ISBN 978-0443066771.
  2. URL: http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm. Accessed on: 18 May 2010.
  3. Bar-Shira Maymon B, Yavetz H, Yogev L, et al. (2005). "Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia". Acta Histochem. 107 (2): 105–12. doi:10.1016/j.acthis.2005.02.002. PMID 15950053.
  4. Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN (September 2003). "Melan-A (A103) and inhibin expression in ovarian neoplasms". Appl. Immunohistochem. Mol. Morphol. 11 (3): 244–9. PMID 12966351.