Difference between revisions of "Radiation oncology"
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'''Radiation oncology''' is a place where people go after the pathologist has | '''Radiation oncology''' is a place where people go after the [[pathologist]] has [[diagnosis|diagnosed]] it as [[cancer]]. | ||
==Dose== | ==Dose== | ||
* | *Measured with several units. | ||
===Gray=== | ===Gray=== | ||
| Line 12: | Line 12: | ||
===Sievert=== | ===Sievert=== | ||
*Abbreviated ''Sv''. | *Abbreviated ''Sv''. | ||
*"Biologic effect"/mass.<ref>{{Ref PCPBoD8|222}}</ref> | *"Biologic effect"/mass.<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref> | ||
<math>Sv = X \cdot dose</math> | <math>Sv = X \cdot dose</math> | ||
| Line 20: | Line 20: | ||
*dose = dose in Gray. | *dose = dose in Gray. | ||
===Typical | ===Typical doses=== | ||
Single dose:<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref> | |||
*<0.5 Gy no histologic change. | |||
*1-2 Gy proliferating cells die. | |||
*10 Gy overt necrosis. | |||
Total: | |||
*Solid tumours ~ 60 to 80 Gy. | *Solid tumours ~ 60 to 80 Gy. | ||
*Lymphoma ~ 20 to 40 Gy. | *[[Lymphoma]] ~ 20 to 40 Gy. | ||
==Biology== | |||
*DNA damage is thought to depend on reactive oxygen species. | |||
**Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.<ref name=Ref_PCPBoD8_222>{{Ref PCPBoD8|222}}</ref> | |||
==See also== | ==See also== | ||
*[[Oncology]]. | *[[Oncology]]. | ||
*[[Radiation colitis]]. | |||
*[[Radiation changes]]. | |||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
==External links== | |||
*[http://en.wikibooks.org/wiki/Radiation_Oncology Radiation oncology (wikibooks.org)] - has substantial content and includes the AJCC staging. | |||
[[Category:Clinical]] | [[Category:Clinical]] | ||
Latest revision as of 12:31, 8 October 2013
Radiation oncology is a place where people go after the pathologist has diagnosed it as cancer.
Dose
- Measured with several units.
Gray
- Abbreviated Gy.
- Energy/mass.
Sievert
- Abbreviated Sv.
- "Biologic effect"/mass.[1]
Where:
- X = fiddle factor for type of tissue and type of radiation.
- dose = dose in Gray.
Typical doses
Single dose:[1]
- <0.5 Gy no histologic change.
- 1-2 Gy proliferating cells die.
- 10 Gy overt necrosis.
Total:
- Solid tumours ~ 60 to 80 Gy.
- Lymphoma ~ 20 to 40 Gy.
Biology
- DNA damage is thought to depend on reactive oxygen species.
- Therefore, poorly oxygenated and poorly vascularized tissues are less sensitive to radiation exposures/treatments.[1]
See also
References
- ↑ 1.0 1.1 1.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 222. ISBN 978-1416054542.
External links
- Radiation oncology (wikibooks.org) - has substantial content and includes the AJCC staging.