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Difference between revisions of "Urothelium"
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→Urothelial carcinoma in situ
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*Urothelial carcinoma in situ (high-grade dysplasia). | *Urothelial carcinoma in situ (high-grade dysplasia). | ||
*Invasive urothelial carcinoma. | *Invasive urothelial carcinoma. | ||
==Mild urothelial atypia in normal urothelium== | |||
===General=== | |||
*May be confused with [[urothelial carcinoma in situ]].<ref name=Ref_Amin2-57>{{Ref Amin|2-57}}</ref> | |||
*Uncommon. | |||
===Microscopic=== | |||
Features:<ref name=Ref_Amin2-57>{{Ref Amin|2-57}}</ref> | |||
*Umbrella cells have: | |||
**Mild nuclear enlargement ~3-4x lymphocyte. | |||
**Round/regular nuclear membranes. | |||
**Focally clear cytoplasm with cobwebs. | |||
***Clear cytoplasm with eosinophilic reticulations. | |||
*+/-Inflammation. | |||
*No mitotic activity. | |||
DDx: | |||
*[[Urothelial carcinoma in situ]]. | |||
===IHC=== | |||
*CK20 -ve. | |||
*Ki-67 low. | |||
*p53 -ve. | |||
==Urothelial carcinoma in situ== | ==Urothelial carcinoma in situ== | ||