Difference between revisions of "Phosphaturic mesenchymal tumour, mixed connective tissue type"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22927293/> | Features:<ref name=pmid22927293/><ref name=pmid19828339/> | ||
*Spindle cells without atypia in an eosinophilic matrix. | *Spindle cells without atypia in an eosinophilic matrix. | ||
*Osteoclast-type [[giant cell]]s. | *Osteoclast-type [[giant cell]]s. | ||
Revision as of 11:43, 19 August 2013
| Phosphaturic mesenchymal tumour, mixed connective tissue type | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | spindle cells without atypia |
| IHC | vimentin +ve |
| Site | soft tissue, bone |
|
| |
| Blood work | low serum phosphate |
Phosphaturic mesenchymal tumour, mixed connective tissue type, abbreviated PMTMCT, is a rare tumour.
General
- Extremely rare.
- Hypophosphatemia.[1]
- Most common cause of oncogenic osteomalacia (tumour-induced osteomalacia).[2]
Gross
Microscopic
- Spindle cells without atypia in an eosinophilic matrix.
- Osteoclast-type giant cells.
- +/-Calcifications.
Image:
IHC
- Vimentin +ve.[5]
References
- ↑ Papierska, L.; Ćwikła, JB.; Misiorowski, W.; Rabijewski, M.; Sikora, K.; Wanyura, H. (2013). "Unusual case of phosphaturic mesenchymal tumor.". Pol Arch Med Wewn 123 (5): 255-6. PMID 23722193.
- ↑ 2.0 2.1 William, J.; Laskin, W.; Nayar, R.; De Frias, D. (Aug 2012). "Diagnosis of phosphaturic mesenchymal tumor (mixed connective tissue type) by cytopathology.". Diagn Cytopathol 40 Suppl 2: E109-13. doi:10.1002/dc.21647. PMID 22927293.
- ↑ Jiang, Y.; Xia, WB.; Xing, XP.; Silva, BC.; Li, M.; Wang, O.; Zhang, HB.; Li, F. et al. (Sep 2012). "Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature.". J Bone Miner Res 27 (9): 1967-75. doi:10.1002/jbmr.1642. PMID 22532501.
- ↑ Ledford, CK.; Zelenski, NA.; Cardona, DM.; Brigman, BE.; Eward, WC. (Jul 2013). "The Phosphaturic Mesenchymal Tumor: Why is Definitive Diagnosis and Curative Surgery Often Delayed?". Clin Orthop Relat Res. doi:10.1007/s11999-013-3178-1. PMID 23868423.
- ↑ 5.0 5.1 5.2 Woo, VL.; Landesberg, R.; Imel, EA.; Singer, SR.; Folpe, AL.; Econs, MJ.; Kim, T.; Harik, LR. et al. (Dec 2009). "Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature.". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108 (6): 925-32. doi:10.1016/j.tripleo.2009.07.005. PMID 19828339.