Difference between revisions of "Mixed germ cell tumour"

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*† Numbers vary between sources. One series suggests it is almost 70%.<ref name=pmid15017200>{{Cite journal  | last1 = Mosharafa | first1 = AA. | last2 = Foster | first2 = RS. | last3 = Leibovich | first3 = BC. | last4 = Ulbright | first4 = TM. | last5 = Bihrle | first5 = R. | last6 = Einhorn | first6 = LH. | last7 = Donohue | first7 = JP. | title = Histology in mixed germ cell tumors. Is there a favorite pairing? | journal = J Urol | volume = 171 | issue = 4 | pages = 1471-3 | month = Apr | year = 2004 | doi = 10.1097/01.ju.0000116841.30826.85 | PMID = 15017200 }}</ref>
*† Numbers vary between sources. One series suggests it is almost 70%.<ref name=pmid15017200>{{Cite journal  | last1 = Mosharafa | first1 = AA. | last2 = Foster | first2 = RS. | last3 = Leibovich | first3 = BC. | last4 = Ulbright | first4 = TM. | last5 = Bihrle | first5 = R. | last6 = Einhorn | first6 = LH. | last7 = Donohue | first7 = JP. | title = Histology in mixed germ cell tumors. Is there a favorite pairing? | journal = J Urol | volume = 171 | issue = 4 | pages = 1471-3 | month = Apr | year = 2004 | doi = 10.1097/01.ju.0000116841.30826.85 | PMID = 15017200 }}</ref>
*There has been in increase in MGCTs over the past 20 years that is probably due to changes how in how [[germ cell tumours|GCT]]s are classified classification.<ref name=pmid21623833>{{Cite journal  | last1 = Trabert | first1 = B. | last2 = Stang | first2 = A. | last3 = Cook | first3 = MB. | last4 = Rusner | first4 = C. | last5 = McGlynn | first5 = KA. | title = Impact of classification of mixed germ-cell tumours on incidence trends of non-seminoma. | journal = Int J Androl | volume = 34 | issue = 4 Pt 2 | pages = e274-7 | month = Aug | year = 2011 | doi = 10.1111/j.1365-2605.2011.01187.x | PMID = 21623833 }}</ref>  
*There has been in increase in MGCTs over the past 20 years that is probably due to changes how in how [[germ cell tumours|GCT]]s are classified.<ref name=pmid21623833>{{Cite journal  | last1 = Trabert | first1 = B. | last2 = Stang | first2 = A. | last3 = Cook | first3 = MB. | last4 = Rusner | first4 = C. | last5 = McGlynn | first5 = KA. | title = Impact of classification of mixed germ-cell tumours on incidence trends of non-seminoma. | journal = Int J Androl | volume = 34 | issue = 4 Pt 2 | pages = e274-7 | month = Aug | year = 2011 | doi = 10.1111/j.1365-2605.2011.01187.x | PMID = 21623833 }}</ref>  
==Microscopic==
==Microscopic==
Features:
Features:

Revision as of 21:34, 20 July 2013

Mixed germ cell tumour
Diagnosis in short

Mixed germ cell tumour. H&E stain.

LM depends on the components
LM DDx other germ cell tumours
IHC variable
Site ovary, testis, mediastinum, other

Signs mass lesion

Mixed germ cell tumour, abbreviated MGCT, is a lesion composed of different germ cell tumours. Most germ cell tumours are mixed.

General

  • 60% of GCTs are mixed. †

Common combinations:

  1. Teratoma + embryonal carcinoma + endodermal sinus tumour (yolk sac tumour) (TEE).
  2. Seminoma + embryonal (SE).
  3. Teratoma + embryonal +(TE).

Memory device: TEE + all combinations have embryonal carcinoma.

Note:

  • † Numbers vary between sources. One series suggests it is almost 70%.[1]
  • There has been in increase in MGCTs over the past 20 years that is probably due to changes how in how GCTs are classified.[2]

Microscopic

Features:

  • Depends on components.

Notes:

  • If one cannot identify the component... it is probably yolk sac as this has so many different patterns.

Images

www:

IHC

  • Beta-hCG +ve - if syncytiotrophoblasts are present.
  • AFP +ve - a yolk sac tumour component is present.
  • GFAP +ve - if neuroepithelium is present.

See also

References

  1. Mosharafa, AA.; Foster, RS.; Leibovich, BC.; Ulbright, TM.; Bihrle, R.; Einhorn, LH.; Donohue, JP. (Apr 2004). "Histology in mixed germ cell tumors. Is there a favorite pairing?". J Urol 171 (4): 1471-3. doi:10.1097/01.ju.0000116841.30826.85. PMID 15017200.
  2. Trabert, B.; Stang, A.; Cook, MB.; Rusner, C.; McGlynn, KA. (Aug 2011). "Impact of classification of mixed germ-cell tumours on incidence trends of non-seminoma.". Int J Androl 34 (4 Pt 2): e274-7. doi:10.1111/j.1365-2605.2011.01187.x. PMID 21623833.