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Difference between revisions of "Urothelium"
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→Papillary urothelial lesions: fix
(→Papillary urothelial lesions: format) |
m (→Papillary urothelial lesions: fix) |
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{| class="wikitable" | {| class="wikitable" | ||
| | | | ||
|'''Papilloma''' | | '''Papilloma''' | ||
|'''PUNLMP''' | | '''PUNLMP''' | ||
|'''low grade PUCC''' | | '''low grade PUCC''' | ||
|'''high grade PUCC''' | | '''high grade PUCC''' | ||
|- | |- | ||
|papillae features | | papillae features | ||
|'''fat papillae''', <br>'''thick FV core''' | | '''fat papillae''', <br>'''thick FV core''' | ||
|'''slender FV core''' | | '''slender FV core''' | ||
|slender FV core, <br>'''thick epithelium''' | | slender FV core, <br>'''thick epithelium''' | ||
|mixed population | | mixed population | ||
|- | |- | ||
|papillae branching | | papillae branching | ||
|rare | | rare | ||
|uncommon | | uncommon | ||
|frequent | | frequent | ||
|common | | common | ||
|- | |- | ||
|papillae fusion | | papillae fusion | ||
|none | | none | ||
|rare | | rare | ||
|some | | some | ||
|common | | common | ||
|- | |- | ||
|nuclear size | | nuclear size | ||
|normal (2x lymphocyte) | | | normal (2x lymphocyte) | | ||
|'''enlarged - uniform''' | | '''enlarged - uniform''' | ||
|'''enlarged with variation''' | | '''enlarged with variation''' | ||
|'''4-5x lymphocyte,'''<br>'''marked pleomorphism''' | | '''4-5x lymphocyte,'''<br>'''marked pleomorphism''' | ||
|- | |- | ||
|mitoses | | mitoses | ||
|very rare basal | | very rare basal | ||
| rare basal only | | rare basal only | ||
|infreq., usually basal | | infreq., usually basal | ||
|common, everywhere | | common, everywhere | ||
|- | |- | ||
|DDx | | DDx | ||
|PUNLMP, low gr. PUCC | | PUNLMP, low gr. PUCC | ||
|papilloma, low gr. | | papilloma, low gr. | ||
|PUNLMP, high gr. | | PUNLMP, high gr. | ||
|low gr., invasive UCC | | low gr., invasive UCC | ||
|- | |- | ||
|IHC | |IHC | ||
|p53-, CK20+ umbrella cells | | p53-, CK20+ umbrella cells | ||
|CK20+ umbrella | | CK20+ umbrella | ||
|-/+ p53, CK20+ umbrella | | -/+ p53, CK20+ umbrella | ||
|'''diffuse CK20+''', p53+ in 50% | | '''diffuse CK20+''', p53+ in 50% | ||
|- | |- | ||
|Other | |Other | ||
|cytologically normal | | cytologically normal | ||
|low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref> | | low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref> | ||
|+/- small nucleoli | | +/- small nucleoli | ||
|nucleoli prominent | | nucleoli prominent | ||
|- | |- | ||
|Key feature | |Key feature | ||
|normal cells,<br>fat papillae | | normal cells,<br>fat papillae | ||
|uniformly enlarged cell pop., <br>slender papillae | | uniformly enlarged cell pop., <br>slender papillae | ||
|nuc. pleomorphism, <br> thick epithelium | | nuc. pleomorphism, <br> thick epithelium | ||
|marked nuclear pleomorphism | | marked nuclear pleomorphism | ||
|- | |- | ||
|} | |} | ||