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Difference between revisions of "Medical liver disease"
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→Drug toxicity: rename
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Image: [http://commons.wikimedia.org/wiki/File:Congestive_hepatopathy_high_mag.jpg Congestive hepatopathy (WC)]. | Image: [http://commons.wikimedia.org/wiki/File:Congestive_hepatopathy_high_mag.jpg Congestive hepatopathy (WC)]. | ||
==Drug | ==Drug-induced liver disease== | ||
* | *Drugs can do almost anything; may include: [[granulomata]], bile duct loss, cholestasis, ischemic type injury. | ||
*Effects can be delayed -- temporal relationship not always obvious. | *Effects can be delayed -- temporal relationship not always obvious. | ||
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**+/-[[Granuloma]]s. | **+/-[[Granuloma]]s. | ||
=== | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Drug-induced_hepatitis_low_mag.jpg Drug-induced hepatitis - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Drug-induced_hepatitis_intermed_mag.jpg Drug-induced hepatitis - intermed. mag. (WC)]. | |||
===Specific patterns=== | |||
Acute hepatits: | Acute hepatits: | ||
*Related to Rx - most often antibiotics. | *Related to Rx - most often antibiotics. | ||
[[Steatohepatitis]]/[[steatosis]]:<ref name=pmid16237810>{{Cite journal | last1 = Grieco | first1 = A. | last2 = Forgione | first2 = A. | last3 = Miele | first3 = L. | last4 = Vero | first4 = V. | last5 = Greco | first5 = AV. | last6 = Gasbarrini | first6 = A. | last7 = Gasbarrini | first7 = G. | title = Fatty liver and drugs. | journal = Eur Rev Med Pharmacol Sci | volume = 9 | issue = 5 | pages = 261-3 | month = | year = | doi = | PMID = 16237810 }}</ref> | |||
*Amiodarone - cardiac arrhythmias. | |||
*Tamoxifen - breast cancer. | |||
*Carbamazepine - seizures. | |||
===Specific drugs=== | |||
Acetaminophen: | Acetaminophen: | ||
*Zone 3 necrosis. | *Zone 3 necrosis. | ||
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**Nuclear atypia (hyperchromasia, pleomorphism, vacuolation). | **Nuclear atypia (hyperchromasia, pleomorphism, vacuolation). | ||
***Described as just nuclear size variation by some.<ref>MG. 23 September 2009.</ref> | ***Described as just nuclear size variation by some.<ref>MG. 23 September 2009.</ref> | ||
==Focal nodular hyperplasia== | ==Focal nodular hyperplasia== | ||