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Difference between revisions of "Thyroid gland"
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→Medullary thyroid carcinoma: more, +gross
m (→Microscopic) |
(→Medullary thyroid carcinoma: more, +gross) |
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*May be genetic (MEN IIa/b syndrome). | *May be genetic (MEN IIa/b syndrome). | ||
*Arises from C cells (which produce calcitonin). | *Arises from C cells (which produce calcitonin). | ||
Syndromic tumours - typically:<ref name=pmid21455198>{{Cite journal | last1 = Nosé | first1 = V. | title = Familial thyroid cancer: a review. | journal = Mod Pathol | volume = 24 Suppl 2 | issue = | pages = S19-33 | month = Apr | year = 2011 | doi = 10.1038/modpathol.2010.147 | PMID = 21455198 |URL = http://www.nature.com/modpathol/journal/v24/n2s/full/modpathol2010147a.html }}</ref> | |||
*Present in 30s or 40s. | |||
*+/-Multifocal. | |||
*+/-Bilateral. | |||
*C-cell hyperplasia. | |||
===Gross=== | |||
Features:<ref name=pmid21455198/> | |||
*Usu. well-circumscribed. | |||
*White, gray or yellow. | |||
*Gritty. | |||
*Firm. | |||
Image: | |||
*[http://www.nature.com/modpathol/journal/v24/n2s/fig_tab/modpathol2010147f2.html MTC (nature.com)]. | |||
===Microscopic=== | ===Microscopic=== | ||
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**Coarse chromatin (''salt and pepper nuclei''). | **Coarse chromatin (''salt and pepper nuclei''). | ||
*+/-[[Amyloid]] deposits - fluffy appearing acellular eosinophilic material in the cytoplasm. | *+/-[[Amyloid]] deposits - fluffy appearing acellular eosinophilic material in the cytoplasm. | ||
*C-cell hyperplasia | **+/-C-cell hyperplasia - seen with familial forms of MTC. | ||
**C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | **C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | ||