Difference between revisions of "Plasma cell"

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Revision as of 02:58, 1 April 2012

The plasma cell is white blood cell that produces antibodies.

Microscopic

Features:

  • Ovoid intermediate-small cell size ~ 12 micrometers:
  • Eccentric nucleus.
    • Nucleus usu. hugs the cell membrane.
    • "Clock-face" chromatin pattern.
      • Small dots symmetrically rim the nuclear membrane - like the numbers on a clock.
  • Abundant cytoplasm.
    • Nucleus-to-cytoplasm ratio ~1:2
    • Perinuclear hof (prominent Gogli apparatus).
      • Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.

Images:

Neoplasia

Neoplasms derived from plasma cell are called plasma cell neoplasms.

IHC

Others:

  • CD19 -ve.
  • CD20 -ve
  • CD56 -ve.

See also

References

  1. 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.