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Difference between revisions of "Uterine cervix"
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# Both perinuclear clearing and nuclear changes are essential. | # Both perinuclear clearing and nuclear changes are essential. | ||
# Benign cells have a small nucleus that is peripheral. | # Benign cells have a small nucleus that is peripheral. | ||
=Cancer= | =Cancer= | ||
| Line 255: | Line 229: | ||
*Uterus (typically): vimentin+, ER+, PR+. | *Uterus (typically): vimentin+, ER+, PR+. | ||
** ... and CEA-, p16-. | ** ... and CEA-, p16-. | ||
=Uncommon non-invasive= | |||
==Stratified mucin-producing intraepithelial lesions of the cervix== | |||
*Abbreviated ''SMILE'' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion). | |||
===General=== | |||
*Rare. | |||
*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/> | |||
===Microscopic=== | |||
Features:<ref name=pmid11023104>{{Cite journal | last1 = Park | first1 = JJ. | last2 = Sun | first2 = D. | last3 = Quade | first3 = BJ. | last4 = Flynn | first4 = C. | last5 = Sheets | first5 = EE. | last6 = Yang | first6 = A. | last7 = McKeon | first7 = F. | last8 = Crum | first8 = CP. | title = Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia? | journal = Am J Surg Pathol | volume = 24 | issue = 10 | pages = 1414-9 | month = Oct | year = 2000 | doi = | PMID = 11023104 }}</ref> | |||
*Stratified epithelium with: | |||
**Nuclear atypia. | |||
**Cytoplasmic clearing or vacuoles in lesions - through-out. | |||
DDx: | |||
*[[HSIL]]. | |||
**Mucin may be present superficially.<ref name=pmid11023104/> | |||
Images: | |||
*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_1.jpg SMILE (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile]. Accessed on: 30 March 2012.</ref> | |||
*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_2.jpg SMILE (sunnybrook.ca)]. | |||
===IHC=== | |||
Features: | |||
*Ki-67 high. | |||
*Keratin 14 -ve. | |||
*p63 +ve/-ve -- only basal if positive. | |||
=Uncommon types of cervical cancer= | =Uncommon types of cervical cancer= | ||