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Difference between revisions of "Heart valves"
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→Microscopic: more IHC, histiocytes/granulomas
(→Microscopic: more IHC, histiocytes/granulomas) |
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| Line 180: | Line 180: | ||
**Jumbled collagen, eosinophilic, and | **Jumbled collagen, eosinophilic, and | ||
**Surrounded by lymphocytes (T cells) +/- plasma cells. | **Surrounded by lymphocytes (T cells) +/- plasma cells. | ||
Notes: | |||
*Anitschkow cells are thought to be histocytes and Aschoff bodies are thought to be [[granuloma]]s.<ref name=pmid3070554>{{Cite journal | last1 = Love | first1 = GL. | last2 = Restrepo | first2 = C. | title = Aschoff bodies of rheumatic carditis are granulomatous lesions of histiocytic origin. | journal = Mod Pathol | volume = 1 | issue = 4 | pages = 256-61 | month = Jul | year = 1988 | doi = | PMID = 3070554 }}</ref> | |||
**This is disputed.<ref name=pmid10399163>{{Cite journal | last1 = Stehbens | first1 = WE. | last2 = Zuccollo | first2 = JM. | title = Anitschkow myocytes or cardiac histiocytes in human hearts. | journal = Pathology | volume = 31 | issue = 2 | pages = 98-101 | month = May | year = 1999 | doi = | PMID = 10399163 }}</ref> | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Aschoff_Body_in_Rheumatic_Myocarditis.jpg Aschoff body (WC)]. | *[http://commons.wikimedia.org/wiki/File:Aschoff_Body_in_Rheumatic_Myocarditis.jpg Aschoff body (WC)]. | ||
*[http://en.wikipedia.org/wiki/File:Anitschkow_Myocytes_in_an_Aschoff_Body,_Rheumatic_Myocarditis.jpg Anitschkow myocytes (WC)]. | *[http://en.wikipedia.org/wiki/File:Anitschkow_Myocytes_in_an_Aschoff_Body,_Rheumatic_Myocarditis.jpg Anitschkow myocytes (WC)]. | ||
===IHC=== | |||
Features (Aschoff bodies & Anitschkow cells):<ref name=pmid3070554>{{Cite journal | last1 = Love | first1 = GL. | last2 = Restrepo | first2 = C. | title = Aschoff bodies of rheumatic carditis are granulomatous lesions of histiocytic origin. | journal = Mod Pathol | volume = 1 | issue = 4 | pages = 256-61 | month = Jul | year = 1988 | doi = | PMID = 3070554 }}</ref> | |||
*S100 -ve. | |||
*Muscle specific actin -ve. | |||
*Desmin -ve. | |||
*NF -ve. | |||
*Vimentin +ve. | |||
*CD45 +ve (weak). | |||
==Infective endocarditis== | ==Infective endocarditis== | ||