View source for Adenoid cystic carcinoma of the breast

{{ Infobox diagnosis
| Name       = {{PAGENAME}}
| Image      = Breast_AdenoidCysticCarcinoma_MP_CTR.jpg
| Width      =
| Caption    = Adenoid cystic carcinoma of the breast. [[H&E stain]].
| Synonyms   =
| Micro      =
| Subtypes   =
| LMDDx      = cribriform [[DCIS]], [[invasive cribriform carcinoma of the breast]], [[collagenous spherulosis]]
| Stains     =
| IHC        =
| EM         =
| Molecular  =
| IF         =
| Gross      =
| Grossing   = [[breast grossing]]
| Staging    = [[breast cancer staging]]
| Site       = [[breast]] - see ''[[invasive breast cancer]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms   =
| Prevalence = very rare
| Bloodwork  =
| Rads       =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx         = surgery
}}
'''Adenoid cystic carcinoma of the breast''' is a rare type of [[breast cancer]] that is similar to a relatively common tumour of the [[salivary gland]].

It is also known as '''breast adenoid cystic carcinoma''', abbreviated '''BACC'''.<ref name=pmid16203286>{{Cite journal  | last1 = Crisi | first1 = GM. | last2 = Marconi | first2 = SA. | last3 = Makari-Judson | first3 = G. | last4 = Goulart | first4 = RA. | title = Expression of c-kit in adenoid cystic carcinoma of the breast. | journal = Am J Clin Pathol | volume = 124 | issue = 5 | pages = 733-9 | month = Nov | year = 2005 | doi = 10.1309/61MV-ENEK-5EJ7-JKGF | PMID = 16203286 }}</ref>

==General==
*Like tumour of the [[salivary gland]].
*Very rare <0.1% of breast malignancies.<ref name=pmid22154460/>
*Good prognosis.<ref name=pmid22154460>{{Cite journal  | last1 = Boujelbene | first1 = N. | last2 = Khabir | first2 = A. | last3 = Boujelbene | first3 = N. | last4 = Jeanneret Sozzi | first4 = W. | last5 = Mirimanoff | first5 = RO. | last6 = Khanfir | first6 = K. | title = Clinical review - Breast adenoid cystic carcinoma. | journal = Breast | volume =  | issue =  | pages =  | month = Dec | year = 2011 | doi = 10.1016/j.breast.2011.11.006 | PMID = 22154460 }}</ref>

==Microscopic==
:See: ''[[Adenoid cystic carcinoma]]'' article.

DDx: 
*Cribriform [[DCIS]].
*[[Invasive cribriform carcinoma of the breast]].
*[[Collagenous spherulosis]].

===Images===

<gallery>
Image:Breast AdenoidCysticCarcinoma 2 LP CTR.jpg|Breast Adenoid Cystic Carcinoma - low power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP CTR (3).jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 MP CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma MP CTR.jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma MP CTR (2).jpg|Breast Adenoid Cystic Carcinoma - medium power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP CTR (2).jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP3 CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma 2 HP2 CTR.jpg|Breast Adenoid Cystic Carcinoma - high power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType LP 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - Low power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - medium power - Aggregates of basaloid cells without tubule or cyst formation.  (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType HP 14BR***.jpg|Breast - Adenoid Cystic Carcinoma -  Solid Type - High power (SKB)
Image:Breast AdenoidCysticCarcinoma SolidType 2 14BR***.jpg|Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB)
</gallery>
www:
*[http://path.upmc.edu/cases/case140.html Adenoid cystic carcinoma of the breast (upmc.edu)].

==IHC==
*One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative.<ref name=pmid16258515>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>
*Basal-like breast cancer - p63 and CK5/6 positive.<ref name=pmid16258515>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>
CD117 positive<ref name=pmid16258515>{{Cite journal  | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref>

==Other Resources==
Pathology Outlines [http://www.pathologyoutlines.com/topic/breastmalignantadenoidcystic.html]

==See also==
*[[Invasive breast carcinoma]].
*[[Adenoid cystic carcinoma]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Invasive breast cancer]]