View source for Case 118

===Provided clinical history===
34 year old female with sudden seizures.

===Site===
Temporal lobe.


===Primary image===
[[Image:Neuropathology case XI 01.jpg |500px|link=|center|]]
<center>Low magnification. [[H&E stain]].</center>

{{hidden|Intermediate magnification|[[Image:Neuropathology case XI 02.jpg |500px|link=|center|]]
<center>Intermediate magnification. [[H&E stain]].</center>}}

{{hidden|Very high magnification|[[Image:Neuropathology case XI 03.jpg |500px|link=|center|]]
<center>High magnification. [[H&E stain]].</center>}}

===Differential diagnosis===
{{hidden|Differential diagnosis|<center>Metastasis, [[Meningioma]], Chordoid Glioma, Chordoma </center>}}

===Additional tests===
====More history====
{{hidden|More history|<center>The tumor has contact to the leptomeninges.</center>}}

====Ask a colleague====
{{hidden|Ask a colleague|<center>Spindle shaped in a mucoid background. Was EMA immunostain positive?</center>}}

====Stains====
{{Case Stains
| blank=Dr White would ask why!
| alcpas= 
| alc1= '''POSITIVE''
| alc25= '''POSITIVE'''
| aur= 
| biel= 
| bili= 
| iron= 
| congored= 
| cresylv= 
| dieterle= 
| diffquik= 
| fontana= 
| gallyas= 
| giemsa= 
| gms= 
| gomori= 
| gram= 
| gremelius= 
| jms= 
| jones= 
| kinyoun= 
| luxol= 
| masson= 
| mmas= 
| movat= 
| mucicar= 
| oilredo= 
| orecein= 
| pas= '''NEGATIVE'''
| pasd= 
| pasf= 
| ptah= 
| prussian= 
| reticulin= 
| sudanblackb= 
| toluidine= 
| verhoeff= 
| vonkossa= 
| warthinstarry= 
| zn= 
}}
====IHC====
{{Case IHC
| blank=Dr White would ask why!
| a1at= 
| acth= 
| ae1ae3= '''NEGATIVE'''
| afp= 
| alk1= 
| amacr= 
| ar=
| atrx= 
| b2microglobulin= 
| b72_3= 
| bcatenin= 
| bcl2= 
| bcl6= 
| bclxl= 
| c3= 
| ca9= 
| calcitonin= 
| calponin= 
| calretinin= '''WEAKLY POSITIVE
| cam5p2= '''NEGATIVE'''
| cathepsink= 
| cd10= 
| cd117= 
| cd138= 
| cd15= 
| cd1a= 
| cd20= 
| cd21= 
| cd23= 
| cd3= 
| cd30= '''NEGATIVE'''
| cd31= '''NEGATIVE'''
| cd34= '''NEGATIVE'''
| cd35= 
| cd4= 
| cd43= 
| cd45= '''NEGATIVE
| cd5= 
| cd56= 
| cd57= 
| cd68= 
| cd7= 
| cd79a= 
| cd8= 
| cd99= 
| cdx2= 
| cea= 
| chromo= 
| ck17= 
| ck19= 
| ck20= 
| ck34be12= 
| ck5_6= 
| ck7= 
| cmv= 
| cmyc= 
| cyclin_d1= 
| d2_40= 
| desmin= 
| dog1= 
| ebv= 
| ema= [[Image:Neuropathology case XI 04.jpg |500px|link=|center|]]
| erpr= 
| f_viii= 
| f_xiiia= 
| fascin= 
| fh=
| fsh= 
| gastrin= 
| gata3= 
| gcdfp= 
| gfap= '''NEGATIVE'''
| gh= 
| glucagon= 
| glypican3= '''NEGATIVE'''
| hbme1= 
| hbv_core= 
| hbv_surf= 
| hcaldesmon= 
| hcg= 
| helicobacter= 
| hepatocyte= 
| her2= 
| hhv8= 
| hmb45= 
| hnf1beta= 
| hpv= 
| hsv1= 
| hsv2= 
| Idh-1= 
| inhibin= 
| ini1= 
| insulin= 
| kappa= 
| ki67= '''8%'''
| lambda= 
| leu7= 
| lga= 
| lgg= 
| lgm= 
| lh= 
| lysozyme= 
| mammogl=
| map2= 
| mcv= 
| melanin_a= '''NEGATIVE'''
| mitf= 
| mum1= 
| myleoperox= 
| myo_d1= 
| myog= 
| nf= 
| nkx3_1= 
| nse= 
| oct3_4=
| p16= 
| p501s= 
| p53= 
| p57= 
| p63= 
| panker= '''NEGATIVE'''
| pax2= 
| pax5= 
| pax8= 
| pcna= 
| pdgfr= 
| plap= 
| pnl-2c= 
| prolactin= 
| psa= 
| psap= 
| rcc= 
| s100= 
| sma= 
| somatsatin= 
| stat6= 
| synapto= 
| tdt= 
| tfe3= 
| tfeb= 
| thyrogl= 
| toxopl= 
| tsh= 
| ttf1= 
| ubiquitin= 
| uchl1= 
| ulex_europe= 
| vim= 
| vip= 
| vzv= 
| wt1= 
}}

====Molecular testing====
=====Chromosomal translocations=====
{{Case Translocations
| blank=Dr White would ask why!
| t1_13= 
| t2_13= 
| t8_14= 
| t9_22bcr_abl= 
| t9_22chn_ews= 
| t11_14= 
| t11_22dsrct= 
| t11_22ews= 
| t12_15= 
| t12_16afh= 
| t12_16liposar= 
| t12_22= 
| t14_18= 
| t15_17= 
| t16_21= 
| t17_22= 
| t21_22= 
| tx_1= 
| tx_17= 
| tx_18= 
}}
=====Other molecular tests=====
{{Case Molecular
| blank=Dr White would ask why!
| alk = 
| b_cell_clone = 
| bcl2 = 
| braf = 
| EBV_pcr = 
| egrf = 
| h3f3a = 
| hhv8_pcr = 
| identity_test = 
| idh1_2 = 
| jak2_v617f = 
| kit = 
| loh_1p19q = 
| t_cell_clone = 
}}

===Diagnosis===
{{hidden|Diagnosis|<center>Chordoid [[meningioma]] WHO grade II</center>
<br>
Comment: Most meningioma subtypes correspond to WHO grade I. Chordoid meningioma is one of the variant that - even in absence of atypia or mitoses - is graded WHO II.}}

===Other cases===
{{Cases navigation}}

__NOTOC__

[[Category:Cases]]

[[Category:Cases in neuropathology]]
[[Category:Cases in neuropathology - junior]]

[[Category:Cases difficulty 3]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level -->