Cutaneous T-cell lymphoma
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Cutaneous T-cell lymphoma, abbreviated CTCL, is a malignant lymphoid neoplasm that arises in the skin.
General
- Mycosis fungoides - is a subtype (???).
- CTCL is more common than cutaneous B-cell lymphoma (CBCL).[1][2]
Stages - like Kaposi sarcoma:
- Patch.
- Plaque.
- Nodular.
Microscopic
- Atypical lymphocytes:
- Have folded "cerebriform" nuclei; Sezary-Lutzner cells.[3]
- Grouping:
- Nests in the epidermis - known as "Pautrier microabscesses".
- Single lymphocytes in epidermis - without accompanying edema.
- Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".[3]
DDx:
Images
CTCL - very high mag. (WC/Nephron)
CTCL - intermed. mag. (WC/Nephron)
www:
IHC
Key stain:
- CD4 +ve.[4]
Other stains:
- CD3 +ve.
- CD8 -ve.
- CD20 -ve (to r/o significant B cell population).
- CD30 -ve.
- CD5 +ve.
- CD7 -ve (often lost first in T cell lymphomas).
- Ki-67 high.
- CD56 -ve.
See also
References
- ↑ URL: http://emedicine.medscape.com/article/1099540-overview. Accessed on: 24 August 2010.
- ↑ URL: http://emedicine.medscape.com/article/1098342-overview. Accessed on: 24 August 2010.
- ↑ 3.0 3.1 Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 385. ISBN 978-1416002741.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1185. ISBN 978-1416031215.