Sinonasal teratocarcinosarcoma

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Sinonasal teratocarcinosarcoma, abbreviated SNTCS is a rare malignant tumour of the neck and neck.

It is also known as teratoid carcinosarcoma and teratocarcinoma.[1]

Sinonasal teratocarcinoma redirects here.

General

  • Estimated to be ~3% of head and neck malignancies.[2]

Gross

  • Typically within nasal cavity/paranasal sinus.[2]
  • May be related to mixed germ cell tumour - as it may have the isochromosome p12.

Microscopic

Features:

  • Malignant teratoma and carcinosarcoma - includes following components:
    • Epithelium.
    • Mesenchyme.
    • Primitive neuroectoderm.

DDx:

Molecular

  • May have isochromosome p12.[3][4]

See also

References

  1. Mohanty, S.; Somu, L.; Gopinath, M. (Jun 2013). "Sino nasal teratocarcinosarcoma-an interesting clinical entity.". Indian J Surg 75 (Suppl 1): 141-2. doi:10.1007/s12262-012-0510-z. PMID 24426542.
  2. 2.0 2.1 Kurmi, DJ.; Mittal, RS.; Sharma, A.; Gandhi, A.; Singhvi, S.. "Sinonasal teratocarcinosarcoma involving nasal cavity, nasopharynx, and all paranasal sinuses with bilateral orbital and intracranial extension: A rare case report.". Asian J Neurosurg 12 (2): 232-240. doi:10.4103/1793-5482.145559. PMID 28484539.
  3. Vranic, S.; Caughron, SK.; Djuricic, S.; Bilalovic, N.; Zaman, S.; Suljevic, I.; Lydiatt, WM.; Emanuel, J. et al. (Nov 2008). "Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature.". BMC Ear Nose Throat Disord 8: 8. doi:10.1186/1472-6815-8-8. PMID 19025657.
  4. Thomas, J.; Adegboyega, P.; Iloabachie, K.; Mooring, JW.; Lian, T. (Apr 2011). "Sinonasal teratocarcinosarcoma with yolk sac elements: a neoplasm of somatic or germ cell origin?". Ann Diagn Pathol 15 (2): 135-9. doi:10.1016/j.anndiagpath.2010.01.004. PMID 20952296.