Salivary gland mucocele

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Salivary gland mucocele, also salivary mucocele and mucocele, is a benign lesion of the head and neck.

Ranula redirects here. A ranula is a mucocele that occurs in the floor mouth.[1]

General

  • Benign.
  • Infected mucocele = mucopyocele.
  • Cancer may mimic a mucocele.[2]

Gross

Features:

  • Floor of mouth lesion.

Images

Microscopic

Features:[3]

  • Granulation tissue-like and pseudocyst-like.
    • Granulation tissue-like:
      • Fibroblasts.
      • Small caliber blood vessels.
      • Histocytes.
      • Neutrophils.
    • Pseudocyst:
      • No epithelial lining.
      • Poorly circumscribed.
  • Pale pink extracellular material (mucous) - key feature.
  • +/-Granulomas.[4]

DDx:

Images

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LESION, LEFT LOWER LIP, EXCISION:
- BENIGN MUCOCELE.

Micro

The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a well-circumscribed cystic lesion.

The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. No significant nuclear atypia is identified. Mitotic activity is not readily apparent.

See also

References

  1. Kokong D, Iduh A, Chukwu I, Mugu J, Nuhu S, Augustine S (June 2017). "Ranula: Current Concept of Pathophysiologic Basis and Surgical Management Options". World J Surg 41 (6): 1476–1481. doi:10.1007/s00268-017-3901-2. PMC 5422487. PMID 28194490. //www.ncbi.nlm.nih.gov/pmc/articles/PMC5422487/.
  2. Sousa Melo SL, Lanzel E, Pagedar NA, Alhazmi D, Dahmoush L, Policeni BA, Campos MS (May 2018). "Mucoepidermoid carcinoma mimicking a mucocele (ranula) in the floor of the mouth". Dentomaxillofac Radiol 47 (4): 20170331. doi:10.1259/dmfr.20170331. PMC 5991757. PMID 29231036. //www.ncbi.nlm.nih.gov/pmc/articles/PMC5991757/.
  3. URL: http://emedicine.medscape.com/article/1076717-workup. Accessed on: 6 March 2012.
  4. Seifert, G.; Donath, K.; von Gumberz, C. (Jun 1981). "[Mucoceles of the minor salivary glands. Extravasation mucoceles (mucus granulomas) and retention mucoceles (mucus retention cysts) (author's transl)].". HNO 29 (6): 179-91. PMID 7251405.