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Epilepsy is a common chronic seizure disorder.


  • Epilepsy = seizures that are "idiopathic", i.e. no brain tumour, no mass lesion, no brain injury.
  • Most common form: temporal lobe epilepsy.[1]






  • Temporal lobe epilepsy
  • Mesial temporal sclerosis = scarring of the medial temporal lobe.
    • Involves: hippocampus, parahippocampal gyrus and amygdala.
  • Granule cell dispersion

Hippocampal sclerosis

  • Most frequent histopathology in temporal lobe epilepsy (33% of all epilepsy surgery specimen).
  • ILAE classification for hippocampus specimen:[5]
    • ILAE type 1: cell loss predominantly in CA1 and CA4 sectors.
    • ILAE type 2: predominant CA1 neuron loss and gliosis.
    • ILAE type 3: CA4 predominant neuronal cell loss and gliosis.

Clinic: ILAE type 1: benefit from epilepsy surgery.


  • Gliosis withot neuronal loss is not considered hippocampal sclerosis.

Granule cell dispersion

  • Affects dentate gyrus.
  • Observed in up to 40% specimen with hippocampal sclerosis.
  • Clinico-pathological classification:[6]
    • Granule cell pathology (GCP) Type 1: Substantial granule cell loss.
    • Granule cell pathology (GCP) Type 2: Cell dispersion, ectopic neurons or clusters of neurons in the molecular layer or bi-lamination.


  • Association with longer epilepsy duration.


Sudden unexpected death in epilepsy

  • Abbreviated SUDEP.



  • Typically poorly controlled epilepsy.
  • Incidence: 0.09-9 per 1000 patient-years.

See also


  1. URL: http://emedicine.medscape.com/article/342150-overview. Accessed on: 20 November 2010.
  2. Cataltepe, O.; Turanli, G.; Yalnizoglu, D.; Topçu, M.; Akalan, N. (Apr 2005). "Surgical management of temporal lobe tumor-related epilepsy in children.". J Neurosurg 102 (3 Suppl): 280-7. doi:10.3171/ped.2005.102.3.0280. PMID 15881751.
  3. Im, SH.; Chung, CK.; Cho, BK.; Lee, SK. (Mar 2002). "Supratentorial ganglioglioma and epilepsy: postoperative seizure outcome.". J Neurooncol 57 (1): 59-66. PMID 12125968.
  4. MUN. 15 November 2010.
  5. Blümcke, I.; Thom, M.; Aronica, E.; Armstrong, DD.; Bartolomei, F.; Bernasconi, A.; Bernasconi, N.; Bien, CG. et al. (Jul 2013). "International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods.". Epilepsia 54 (7): 1315-29. doi:10.1111/epi.12220. PMID 23692496.
  6. Blümcke, I.; Kistner, I.; Clusmann, H.; Schramm, J.; Becker, AJ.; Elger, CE.; Bien, CG.; Merschhemke, M. et al. (May 2009). "Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies.". Acta Neuropathol 117 (5): 535-44. doi:10.1007/s00401-009-0512-5. PMID 19277686.
  7. Tomson, T.; Nashef, L.; Ryvlin, P. (Nov 2008). "Sudden unexpected death in epilepsy: current knowledge and future directions.". Lancet Neurol 7 (11): 1021-31. doi:10.1016/S1474-4422(08)70202-3. PMID 18805738.