Stratified mucin-producing intraepithelial lesion of the cervix
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Stratified mucin-producing intraepithelial lesion of the cervix is a rare dysplastic lesion of the uterine cervix. It is considered to be a high-grade lesion with overlapping features of endocervical adenocarcinoma in situ and squamous intraepithelial lesion.[1]
It is abbreviated SMILE (Stratified Mucin-producing Intraepithelial LEsion).
General
- Rare ~0.6% of cervix lesions in one series.[1]
- Often accompanied by cervical intraepithelial neoplasia and adenocarcinoma in situ.[2]
Management:
- Like endocervical AIS.[1]
Microscopic
Features:[2]
- Stratified epithelium with:
- Nuclear atypia.
- Cytoplasmic clearing or vacuoles in lesions - through-out.
DDx:
- HSIL.
- Mucin may be present superficially.[2]
- Endocervical AIS.
Images
IHC
Features:
- Ki-67 high.
- Keratin 14 -ve.
- p63 +ve/-ve -- only basal if positive.
See also
References
- ↑ 1.0 1.1 1.2 Boyle, DP.; McCluggage, WG. (Apr 2015). "Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings.". Histopathology 66 (5): 658-63. doi:10.1111/his.12498. PMID 25039487.
- ↑ 2.0 2.1 2.2 Park, JJ.; Sun, D.; Quade, BJ.; Flynn, C.; Sheets, EE.; Yang, A.; McKeon, F.; Crum, CP. (Oct 2000). "Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia?". Am J Surg Pathol 24 (10): 1414-9. PMID 11023104.
- ↑ URL: http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile. Accessed on: 30 March 2012.