Stratified mucin-producing intraepithelial lesion of the cervix

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Stratified mucin-producing intraepithelial lesion of the cervix is a rare dysplastic lesion of the uterine cervix. It is considered to be a high-grade lesion with overlapping features of endocervical adenocarcinoma in situ and squamous intraepithelial lesion.[1]

It is abbreviated SMILE (Stratified Mucin-producing Intraepithelial LEsion).

General

Management:

Microscopic

Features:[2]

  • Stratified epithelium with:
    • Nuclear atypia.
    • Cytoplasmic clearing or vacuoles in lesions - through-out.

DDx:

Images

IHC

Features:

  • Ki-67 high.
  • Keratin 14 -ve.
  • p63 +ve/-ve -- only basal if positive.

See also

References

  1. 1.0 1.1 1.2 Boyle, DP.; McCluggage, WG. (Apr 2015). "Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings.". Histopathology 66 (5): 658-63. doi:10.1111/his.12498. PMID 25039487.
  2. 2.0 2.1 2.2 Park, JJ.; Sun, D.; Quade, BJ.; Flynn, C.; Sheets, EE.; Yang, A.; McKeon, F.; Crum, CP. (Oct 2000). "Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia?". Am J Surg Pathol 24 (10): 1414-9. PMID 11023104.
  3. URL: http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile. Accessed on: 30 March 2012.