Rheumatoid lung nodule

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Rheumatoid lung nodule
Diagnosis in short

LM mixed inflammatory infiltrate, +/-giant cells, no micro-organisms
LM DDx necrotic pulmonary nodules in Crohn's disease, infectious pneumonia, amyloidosis of lung
Stains ZN -ve, GMS -ve
Site lung - see medical lung diseases

Associated Dx rheumatoid arthritis
Clinical history +/-hx of rheumatoid arthritis
Prevalence uncommon
Radiology upper lung fields, peripheral, round, +/-cavitation
Clin. DDx only lung lesions - esp. malignancy

Rheumatoid lung nodule, also rheumatoid nodule of the lung and pulmonary rheumatoid nodule, is an uncommon benign lung lesion associated with rheumatoid arthritis.

Rheumatoid lung disease redirects here. Rheumatoid pleuritis is dealt with separately.


Common associations:[1]



  • Usually upper lung fields, peripheral and round.
  • +/-Cavitation (~50% of cases).



  • Mixed inflammatory infiltrate.
  • +/-Giant cells.
  • No micro-organisms.





See also


  1. 1.0 1.1 1.2 Gómez Herrero, H.; Arraiza Sarasa, M.; Rubio Marco, I.; García de Eulate Martín-Moro, I.. "Pulmonary rheumatoid nodules: presentation, methods, diagnosis and progression in reference to 5 cases.". Reumatol Clin 8 (4): 212-5. doi:10.1016/j.reuma.2011.09.004. PMID 22265461.
  2. 2.0 2.1 2.2 Chhakchhuak, CL.; Khosravi, M.; Lohr, KM. (2013). "Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature.". Case Rep Rheumatol 2013: 621340. doi:10.1155/2013/621340. PMID 23984160.
  3. Tokunaga T, Takeda S, Sawabata N, Inoue M, Maeda H (September 2006). "Nodular pulmonary amyloidosis". Jpn J Thorac Cardiovasc Surg 54 (9): 399–401. doi:10.1007/s11748-006-0015-4. PMID 17037396.
  4. Calatayud J, Candelas G, Gómez A, Morado C, Trancho FH (October 2007). "Nodular pulmonary amyloidosis in a patient with rheumatoid arthritis". Clin Rheumatol 26 (10): 1797–8. doi:10.1007/s10067-007-0552-y. PMID 17332981.