Papillary adenoma of the kidney

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Papillary adenoma of the kidney
Diagnosis in short

Papillary adenoma. H&E stain.

Synonyms papillary adenoma, renal papillary adenoma

LM papillae typically with foam cells, +/-psammoma bodies, low ISUP nucleolar grade, must be <=1.5 cm
LM DDx papillary renal cell carcinoma, metanephric adenoma
IHC AMACR +ve
Gross typically subcapsular location
Site kidney - see kidney tumours

Associated Dx often seen with papillary renal cell carcinoma
Clinical history often an incidental finding
Prevalence common
Prognosis benign
Clin. DDx other renal tumours
Treatment observation

Papillary adenoma of the kidney, also renal papillary adenoma, is a benign kidney tumour related to papillary renal cell carcinoma.

General

Note:

Gross

  • Cortical kidney lesion.
    • Usually subcapsular.

Microscopic

Features:

  1. Histomorphology of papillary renal cell carcinoma with low ISUP nucleolar grade (grade 1 or 2).
  2. Must be <=1.5 cm as per 2016 WHO classification.[3]

Note:

  • The size cut-off used to be <=0.5 cm.[3][4][2]

DDx:

Images

www:

IHC

  • CK7 +ve.
  • AMACR +ve.[1]

See also

References

  1. 1.0 1.1 Wang, KL.; Weinrach, DM.; Luan, C.; Han, M.; Lin, F.; Teh, BT.; Yang, XJ. (Feb 2007). "Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.". Hum Pathol 38 (2): 239-46. doi:10.1016/j.humpath.2006.07.016. PMID 17056094.
  2. 2.0 2.1 2.2 Algaba, F. (2008). "Renal adenomas: pathological differential diagnosis with malignant tumors.". Adv Urol: 974848. doi:10.1155/2008/974848. PMC 2563151. PMID 18846240. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2563151/.
  3. 3.0 3.1 Moch, H.; Cubilla, AL.; Humphrey, PA.; Reuter, VE.; Ulbright, TM. (Feb 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.". Eur Urol. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.
  4. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 288. ISBN 978-0443066771.