High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate
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High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate, abbreviated PIN-like adenocarcinoma, is an uncommon type of prostate cancer that histomorphologically mimics high-grade prostatic intraepithelial neoplasia (HGPIN).
General
- Described in ~2006.[1][2]
- May be confused with prostatic intraepithelial neoplasia (PIN).[3]
Microscopic
- Columnar cells with pseudostratified nuclei.
- Non-columnar cells with round nuclei also described.
- Simple glands: flat, tufted or micropapillary.
Note:
- Vaguely similar to a tubular adenoma of the colon.
DDx:
- HGPIN - has basal cells or a few glands.
- Ductal adenocarcinoma of the prostate - papillary architecture.
Image
See also
References
- ↑ 1.0 1.1 Hameed, O.; Humphrey, PA. (Jul 2006). "Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia.". Mod Pathol 19 (7): 899-906. doi:10.1038/modpathol.3800601. PMID 16607376.
- ↑ Lee, TK.; Miller, JS.; Epstein, JI. (Jun 2010). "Rare histological patterns of prostatic ductal adenocarcinoma.". Pathology 42 (4): 319-24. doi:10.3109/00313021003767314. PMID 20438402.
- ↑ 3.0 3.1 Tavora, F.; Epstein, JI. (Jul 2008). "High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases.". Am J Surg Pathol 32 (7): 1060-7. doi:10.1097/PAS.0b013e318160edaf. PMID 18496142.