Mucinous borderline tumour of the ovary
(Redirected from Ovarian mucinous tumour of low malignant potential)
Jump to navigation
Jump to search
Mucinous borderline tumour of the ovary is an ovarian tumour with a low malignant potential.
It is also known as ovarian mucinous borderline tumour and ovarian mucinous tumour of low malignant potential.[1]
General
- Requires extensive sampling - to avoid missing an adenocarcinoma.
Note:
- The WHO prefers borderline over low malignant potential as the descriptor for these tumours.[2]
Classification
Subdivided into:[3]
- Intestinal type mucinous borderline tumour of the ovary ~ 90% of cases.
- Endocervical type mucinous borderline tumour of the ovary ~ 10% of cases.[4]
Gross
Intestinal type mucinous borderline tumour of the ovary and endocervical type mucinous borderline tumour of the ovary:
- Complex multiloculated mass with mucin.
- Often large - may > 30 cm.
Microscopic
Intestinal type mucinous borderline tumour of the ovary
Features:
- Mucinous differentiation:
- Tall columnar cells with apical mucin - usu. resembles gastric foveolar epithelium.
- Layering of epithelial cells (stratification).
- Must be <= 3 cells.[5]
- +/-Papillary infoldings.
- Projections into the cystic space.
- +/-Mild nuclear atypia.
- +/-Mitoses (focally).
Notes:
- Resembles a villous adenoma of the colon.[6]
- Borderline component must be >= 10% of the tumour.[6]
- Lesions with <10% borderline component are known as mucinous cystadenoma of the ovary with focal proliferation or mucinous cystadenoma of the ovary with focal atypia.
DDx:
- Mucinous adenocarcinoma of the ovary.
- Mucinous cystadenoma of the ovary.
- Mucinous cystadenoma of the ovary with focal proliferation.
Endocervical type mucinous borderline tumour of the ovary
Features:[7]
- Cells with mucinous differentiation resembling endocervical epithelium:
- Tall columnar cells with grey apical mucin.
- Cells with eosinophilic cytoplasm - known as "pink cells".
- Ciliated cells.
- Neutrophils associated with the epithelium/mucin - common.[8]
Comparing intestinal versus endocervical
Feature | Intestinal | Endocervical |
---|---|---|
Primary mucin producing cell | clear - well-diff. component, eosinophilic (pink) | eosinophilic (pink), grey or clear |
Size | tall columnar (height:width >3:1) "champagne flute" | stubby columnar (height:width <3:1) |
Accompanying epithelial cells | +/-goblet cells | pink cells, ciliated cells |
Other cells | none | neutrophils (intraepithelial) - common |
Images |
Molecular
- KRAS mutations common ~ 73% of mucinous borderline tumours in one series.[9]
Sign out
OVARY AND CYST, LEFT, OOPHORECTOMY: - MUCINOUS BORDERLINE TUMOUR, INTESTINAL TYPE, ARISING FROM A MUCINOUS CYSTADENOMA (INTESTINAL TYPE). - OVARIAN PARENCHYMA.
See also
References
- ↑ Khunamornpong, S.; Settakorn, J.; Sukpan, K.; Suprasert, P.; Siriaunkgul, S. (May 2011). "Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.". Int J Gynecol Pathol 30 (3): 218-30. doi:10.1097/PGP.0b013e3181fcf01a. PMID 21464732.
- ↑ Acs, G. (Jun 2005). "Serous and mucinous borderline (low malignant potential) tumors of the ovary.". Am J Clin Pathol 123 Suppl: S13-57. PMID 16100867.
- ↑ Rodriguez, IM.; Irving, JA.; Prat, J. (Oct 2004). "Endocervical-like mucinous borderline tumors of the ovary: a clinicopathologic analysis of 31 cases.". Am J Surg Pathol 28 (10): 1311-8. PMID 15371946.
- ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 419. ISBN 978-0443069208.
- ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 416. ISBN 978-0443069208.
- ↑ 6.0 6.1 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 416. ISBN 978-0443069208.
- ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 420. ISBN 978-0443069208.
- ↑ URL: http://www.webpathology.com/image.asp?n=12&Case=526. Accessed on: 9 January 2013.
- ↑ Cuatrecasas, M.; Villanueva, A.; Matias-Guiu, X.; Prat, J. (Apr 1997). "K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.". Cancer 79 (8): 1581-6. PMID 9118042.