Mucinous cystadenoma of the ovary

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Mucinous cystadenoma of the ovary
Diagnosis in short

Ovarian mucinous cystadenoma. H&E stain.
LM cysts lined by a simple mucinous epithelium, no cytologic atypia
LM DDx seromucinous borderline tumour of the ovary, mucinous borderline tumour of the ovary
Molecular +/-KRAS mutation
Gross multiloculated cystic lesion, thin cyst walls/no solid areas
Site ovary - see ovarian tumours
Prevalence common
Prognosis benign
Clin. DDx other ovarian tumours - esp. mucinous ones, and mucinous appendiceal lesions
Treatment cystectomy/oophorectomy

Mucinous cystadenoma of the ovary, also ovarian mucinous cystadenoma, is a common benign ovarian tumour.

It is unrelated to mucinous cystadenoma of the appendix.

General

  • Common.[1]
    • Approximately 80% of all mucinous ovarian tumours.[2]
  • Benign.

Gross

  • Usually multiloculated.
  • May be very large large.[3]
  • No solid areas/thin cyst walls.

Images

  • Mucinous cystadenoma of the ovary. (WC)

Microscopic

Features:

  • Cysts lined by a simple mucinous epithelium.
  • No cytologic atypia.

Note:

  • A borderline component may be present but must be <10% of the tumour.[4]
    • Lesions with <10% borderline component are known as mucinous cystadenoma of the ovary with focal proliferation or mucinous cystadenoma of the ovary with focal atypia.

DDx:

Images

  • OMC - low mag.

  • OMC - low mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - high mag.

  • OMC - very high mag.

Molecular

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Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma.

Mucinous cystadenoma with focal proliferation

Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma with focal proliferation, see comment.

Comment:
The proliferative component is less than 10% of the lesion.

See also

References

  1. ↑ Pongsuvareeyakul, T.; Khunamornpong, S.; Settakorn, J.; Sukpan, K.; Suprasert, P.; Siriaunkgul, S. (Mar 2012). "Accuracy of frozen-section diagnosis of ovarian mucinous tumors.". Int J Gynecol Cancer 22 (3): 400-6. doi:10.1097/IGC.0b013e31823dc328. PMID 22246404.
  2. ↑ Hart WR (January 2005). "Mucinous tumors of the ovary: a review". Int. J. Gynecol. Pathol. 24 (1): 4–25. PMID 15626914.
  3. ↑ Leys, CM.; Gasior, AC.; Hornberger, LL.; St Peter, SD. (Apr 2012). "Laparoscopic resection of massive ovarian mucinous cystadenoma.". J Laparoendosc Adv Surg Tech A 22 (3): 307-10. doi:10.1089/lap.2011.0435. PMID 22283565.
  4. ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 416. ISBN 978-0443069208.
  5. ↑ Cuatrecasas, M.; Villanueva, A.; Matias-Guiu, X.; Prat, J. (Apr 1997). "K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.". Cancer 79 (8): 1581-6. PMID 9118042.

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