Nested urothelial carcinoma
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Nested urothelial carcinoma (abbreviated nested UC), also nested urothelial cell carcinoma (abbreviated nested UCC), is an aggressive subtype of urothelial carcinoma that has a bland morphology but an aggressive behaviour.
It is also known as nested variant of urothelial cell carcinoma.
General
- Aggressive behaviour despite bland histomorphology.[1]
Microscopic
Features:[2]
- High density of well-circumscribed nests.
- Mild-to-moderate nuclear atypia.
- +/-Foci of unequivocal conventional urothelial carcinoma.
- Focally solid or gland fusion.
- Moderate-to-severe nuclear atypia +/- abundant mitoses.
- +/-Extension into the muscularis propria.
DDx:
- von Brunn nests.[3]
- Low grade papillary urothelial carcinoma with lamina propria invasion.
Images
Nested variant of urothelial carcinoma - intermed. mag. (WC/Nephron)
Nested variant of urothelial carcinoma - high mag. (WC/Nephron)
Nested variant of urothelial carcinoma - very high mag. (WC/Nephron)
IHC
- MIB-1 typically >15%.[1]
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URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION OF BLADDER TUMOUR (TURBT):
- INVASIVE LOW-GRADE UROTHELIAL CARCINOMA, NESTED VARIANT.
- TUMOUR PRESENT AT EDGE OF TISSUE.
- NO MUSCULARIS PROPRIA IDENTIFIED.
See also
References
- ↑ 1.0 1.1 Lin, O.; Cardillo, M.; Dalbagni, G.; Linkov, I.; Hutchinson, B.; Reuter, VE. (Dec 2003). "Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases.". Mod Pathol 16 (12): 1289-98. doi:10.1097/01.MP.0000094091.04541.FC. PMID 14681330.
- ↑ Talbert, ML.; Young, RH. (May 1989). "Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases.". Am J Surg Pathol 13 (5): 374-81. PMID 2712189.
- ↑ Cox, R.; Epstein, JI. (Sep 2011). "Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.". Am J Surg Pathol 35 (9): 1337-42. doi:10.1097/PAS.0b013e318222a653. PMID 21836490.