Mixed neuroendocrine-nonneuroendocrine neoplasm

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Mixed neuroendocrine-nonneuroendocrine neoplasm, abbreviated MiNEN, is rare malignant neuroendocrine neoplasm that is a subset of poorly differentiated neuroendocrine carcinoma.[1]


These tumours have gone by many different names - including:[2]

  • Mixed adenoneuroendocrine carcinoma (MANEC).
  • Signet ring cell carcinoid.
  • Composite carcinoid-adenocarcinoma.
  • Mixed adenocarcinoid tumour.

See also


  1. de Mestier, L.; Cros, J.; Neuzillet, C.; Hentic, O.; Egal, A.; Muller, N.; Bouché, O.; Cadiot, G. et al. (Aug 2017). "Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.". Neuroendocrinology. doi:10.1159/000475527. PMID 28803232.
  2. La Rosa, S.; Sessa, F.; Uccella, S. (Dec 2016). "Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.". Endocr Pathol 27 (4): 284-311. doi:10.1007/s12022-016-9432-9. PMID 27169712.