Clear cell carcinoma of the urinary bladder

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Clear cell carcinoma of the urinary bladder
Diagnosis in short
Synonyms mesonephroid adenocarcinoma, mesonephroid carcinoma
Subtypes subtype of primary adenocarcinoma of the urinary bladder
LM DDx nephrogenic adenoma, other subtypes of adenocarcinoma of the urinary bladder, urachal carcinoma, metastatic carcinoma
Site urinary bladder
Clinical history typically female
Prevalence very rare - case reports
Prognosis poor (?)

Clear cell carcinoma of the urinary bladder is a rare subtype of primary adenocarcinoma of the urinary bladder.

It is also known as mesonephroid adenocarcinoma of the urinary bladder, adenocarcinoma of bladder, mesonephroid type and mesonephroid carcinoma.

It is described as the malignant counterpart of nephrogenic adenoma.[1]

General

  • Extremely rare.
    • 7 cases reported as of 2013 according to one study.[2]
    • 19 cases reported as of 2007 according to another study.[1]
    • 47 cases reported as of 2014 according to a third study.[3]
  • Female predominance (F:M ~ 2:1).[2]

Microscopic

Features:[2]

  • Clear cells with moderate atypia.
    • Clear cell component may be minimal.
  • Gland forming lesion.
  • +/-Hobnailing of lining cells (suggestive).

DDx:

Images

IHC

Features:

  • CK7 +ve.
  • CD10 +ve.
  • CA-125 +ve.
  • GATA3 +ve.

Others:

  • ER -ve.
  • PR -ve.
  • CDX2 -ve.
  • AFP -ve.
  • PSA -ve.

See also

References

  1. ↑ 1.0 1.1 Bannowsky, A.; Wefer, B.; Osmonov, D.; Sotelino, JA.; Filippow, N.; Naumann, CM.; van der Horst, Ch.; Jünemann, KP. et al. (May 2007). "[Mesonephroid carcinoma of the urinary bladder (clear cell carcinoma). Two case reports and review of the literature in a rare variation of the primary adenocarcinoma].". Aktuelle Urol 38 (3): 247-51. doi:10.1055/s-2006-932177. PMID 17516385.
  2. ↑ 2.0 2.1 2.2 2.3 Abbas, M.; Kramer, MW.; Wolters, M.; Herrman, TR.; Becker, JU.; Kreipe, HH. (Feb 2013). "Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case.". Rare Tumors 5 (1): e3. doi:10.4081/rt.2013.e3. PMID 23772302.
  3. ↑ Venyo, AK. (2014). "Primary Clear Cell Carcinoma of the Urinary Bladder.". Int Sch Res Notices 2014: 593826. doi:10.1155/2014/593826. PMID 27379325.

External links

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