Exaggerated placental site

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Exaggerated placental site, abbreviated EPS, is an uncommon benign pathology that is a gestational trophoblastic disease.

It was previously known as syncytial endometritis.[1][2]

General

  • Benign.

Definition:

Note:

  • Used to go by a terrible old term: syncytial endometritis:[3]
    • Not syncytial -- mostly.
    • Not inflammatory.

Microscopic

Features:[3]

  • Intermediate trophoblast:
    • Abundant (eosinophilic) cytoplasm.
  • Usu. adjacent to:
    • Chorionic villi.
    • Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders.
  • No mitotic activity.
  • Ectatic blood vessels.

DDx:

Image

IHC

  • MIB1 ~0%.
    • Used to differentiate from PSTT.
  • hPL +ve.[2][4]
  • CK18 +ve.[4]

See also

References

  1. URL: http://www.webpathology.com/image.asp?case=565&n=7. Accessed on: 22 May 2014.
  2. 2.0 2.1 Heyderman E, Gibbons AR, Rosen SW (March 1981). "Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy". J. Clin. Pathol. 34 (3): 303–7. PMC 1146481. PMID 7014653. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1146481/.
  3. 3.0 3.1 URL: http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf. Accessed on: 15 August 2011.
  4. 4.0 4.1 Shen DH, Liao XY, Liu YL, Wang H, Yu YZ (October 2004). "[Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule]" (in Chinese). Zhonghua Bing Li Xue Za Zhi 33 (5): 441–4. PMID 15498215.