Mesonephric duct remnant

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Micrograph showing the mesonephric duct remnant. H&E stain.

Mesonephric duct remnant, also Wolffian duct remnant and Gartner duct, a benign embryological remanant that is usually ignored.

Gartner duct cyst, mesonephric duct cyst and Wolffian duct cyst redirect here.

General

Epidemiology:

  • Embryological remnant - benign.
    • Wolffian duct = precursor of male reproductive tract.[1]

Notes:

  • This is not a finding that is reported. The importance of this finding is knowing it isn't something neoplastic.
  • Lame way of remember the synonyms Gartner, Mesonephric, and Wolffian: GMW... it is trying to be a BMW but in girls.

Gross

Schematic showing the location and development of the mesonephric duct (red). (WC/Gray's Anatomy)
  • Classically anterior-lateral wall of the vagina.[2]

Note:

  • Same location as Muellerian cyst.

Microscopic

Features:[3]

  • Small duct -- typically ~50-100 micrometres in diameter.
    • Duct lined by cuboidal cells with moderate eosinophilic cytoplasm.

DDx:

Images

www:

IHC

Features:[4]

  • CD10 +ve.
  • CK7 +ve.
  • PAX2 +ve (nuclear - strong & diffuse).[5]
    • Cancers often lose staining.

See also

References

  1. Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA (2006). "Changes in gene expression during Wolffian duct development". Horm. Res. 65 (4): 200–9. doi:10.1159/000092408. PMID 16567946.
  2. 2.0 2.1 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 97. ISBN 978-0443069208.
  3. Sternberg SE. Histology for Pathologists. 2nd Ed. P.893.
  4. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 442. ISBN 978-0781765275.
  5. Rabban, JT.; McAlhany, S.; Lerwill, MF.; Grenert, JP.; Zaloudek, CJ. (Feb 2010). "PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.". Am J Surg Pathol 34 (2): 137-46. doi:10.1097/PAS.0b013e3181c89c98. PMID 20061933.